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. 2007 May;23(2):99-105.
doi: 10.1016/j.soncn.2007.01.008.

Is there a biological basis for the clustering of symptoms?

Christine Miaskowski  1 , Bradley E Aouizerat
Affiliations

Is there a biological basis for the clustering of symptoms?

Christine Miaskowski et al. Semin Oncol Nurs. 2007 May.

Abstract

Objectives: To examine symptom clusters in oncology patients; to determine if these symptom clusters might share a common biologic mechanism; and to describe potential biologic mechanisms that warrant investigation.

Data sources: Synthesis of the theoretical and research papers on symptom clusters.

Conclusion: Definitive conclusions about whether there is a biologic basis for the clustering of symptoms cannot be determined at this time. The animal model of sickness behavior holds promise as a potential biologic mechanism for clustering symptoms.

Implications for nursing practice: Until more definitive studies of symptom clusters are performed, clinicians need to monitor patients for the co-occurrence of multiple symptoms and develop appropriate management plans.

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