The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
- PMID: 17913510
- DOI: 10.1016/j.critrevonc.2007.07.004
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
Abstract
The link between inflammation and cancer proposed more than a century ago by Rudolf Virchow, who noticed the infiltration of leukocytes in malignant tissues, has recently found a number of genetic and molecular confirmations. Experimental, clinical and epidemiological studies have revealed that chronic inflammation contributes to cancer progression and even predisposes to different types of cancer. Cancer-associated inflammation includes: the presence of leukocyte infiltration; the expression of cytokines such as tumor necrosis factor (TNF) or interleukin (IL)-1; chemokines such as CCL2 and CXCL8; active tissue remodelling and neo-angiogenesis. Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. Many observations indicate that, in the tumor micro-environment, TAM have several protumoral functions, including expression of growth factors, matrix proteases, promotion of angiogenesis and suppression of adaptive immunity. In this review we will discuss the role of TAM in the inflammatory micro-environment of solid tumors and will try to identify potential target for future therapeutic approaches.
Similar articles
-
The role of tumor-associated macrophage in tumor progression.Front Biosci (Schol Ed). 2012 Jan 1;4(2):787-98. doi: 10.2741/s299. Front Biosci (Schol Ed). 2012. PMID: 22202090 Review.
-
Cancer related inflammation: the macrophage connection.Cancer Lett. 2008 Aug 28;267(2):204-15. doi: 10.1016/j.canlet.2008.03.028. Epub 2008 Apr 29. Cancer Lett. 2008. PMID: 18448242 Review.
-
Role of tumor-associated macrophages in tumor progression and invasion.Cancer Metastasis Rev. 2006 Sep;25(3):315-22. doi: 10.1007/s10555-006-9001-7. Cancer Metastasis Rev. 2006. PMID: 16967326 Review.
-
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation.J Leukoc Biol. 2009 Nov;86(5):1065-73. doi: 10.1189/jlb.0609385. Epub 2009 Sep 9. J Leukoc Biol. 2009. PMID: 19741157 Review.
-
Inflammation, microenvironment, and the immune system in cancer progression.Curr Pharm Des. 2009;15(17):1949-55. doi: 10.2174/138161209788453167. Curr Pharm Des. 2009. PMID: 19519435 Review.
Cited by
-
COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.Br J Pharmacol. 2016 Feb;173(4):635-48. doi: 10.1111/bph.13198. Epub 2015 Jul 8. Br J Pharmacol. 2016. PMID: 26013585 Free PMC article. Review.
-
The complex role of macrophages in pancreatic cancer tumor microenvironment: a review on cancer progression and potential therapeutic targets.Discov Oncol. 2024 Aug 26;15(1):369. doi: 10.1007/s12672-024-01256-x. Discov Oncol. 2024. PMID: 39186144 Free PMC article. Review.
-
Tumor-associated macrophages: Role in the pathological process of tumorigenesis and prospective therapeutic use (Review).Biomed Rep. 2020 Nov;13(5):47. doi: 10.3892/br.2020.1354. Epub 2020 Aug 28. Biomed Rep. 2020. PMID: 32934819 Free PMC article. Review.
-
Prognostic Role of C-Reactive Protein In Urological Cancers: A Meta-Analysis.Sci Rep. 2015 Aug 3;5:12733. doi: 10.1038/srep12733. Sci Rep. 2015. PMID: 26235332 Free PMC article.
-
Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression.Front Immunol. 2022 Nov 2;13:1045624. doi: 10.3389/fimmu.2022.1045624. eCollection 2022. Front Immunol. 2022. PMID: 36405712 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
