The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
- PMID: 17913510
- DOI: 10.1016/j.critrevonc.2007.07.004
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
Abstract
The link between inflammation and cancer proposed more than a century ago by Rudolf Virchow, who noticed the infiltration of leukocytes in malignant tissues, has recently found a number of genetic and molecular confirmations. Experimental, clinical and epidemiological studies have revealed that chronic inflammation contributes to cancer progression and even predisposes to different types of cancer. Cancer-associated inflammation includes: the presence of leukocyte infiltration; the expression of cytokines such as tumor necrosis factor (TNF) or interleukin (IL)-1; chemokines such as CCL2 and CXCL8; active tissue remodelling and neo-angiogenesis. Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. Many observations indicate that, in the tumor micro-environment, TAM have several protumoral functions, including expression of growth factors, matrix proteases, promotion of angiogenesis and suppression of adaptive immunity. In this review we will discuss the role of TAM in the inflammatory micro-environment of solid tumors and will try to identify potential target for future therapeutic approaches.
Similar articles
-
The role of tumor-associated macrophage in tumor progression.Front Biosci (Schol Ed). 2012 Jan 1;4(2):787-98. doi: 10.2741/s299. Front Biosci (Schol Ed). 2012. PMID: 22202090 Review.
-
Cancer related inflammation: the macrophage connection.Cancer Lett. 2008 Aug 28;267(2):204-15. doi: 10.1016/j.canlet.2008.03.028. Epub 2008 Apr 29. Cancer Lett. 2008. PMID: 18448242 Review.
-
Role of tumor-associated macrophages in tumor progression and invasion.Cancer Metastasis Rev. 2006 Sep;25(3):315-22. doi: 10.1007/s10555-006-9001-7. Cancer Metastasis Rev. 2006. PMID: 16967326 Review.
-
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation.J Leukoc Biol. 2009 Nov;86(5):1065-73. doi: 10.1189/jlb.0609385. Epub 2009 Sep 9. J Leukoc Biol. 2009. PMID: 19741157 Review.
-
Inflammation, microenvironment, and the immune system in cancer progression.Curr Pharm Des. 2009;15(17):1949-55. doi: 10.2174/138161209788453167. Curr Pharm Des. 2009. PMID: 19519435 Review.
Cited by
-
Polarization of M2 Macrophages by Interaction between Prostate Cancer Cells Treated with Trichomonas vaginalis and Adipocytes.Korean J Parasitol. 2020 Jun;58(3):217-227. doi: 10.3347/kjp.2020.58.3.217. Epub 2020 Jun 26. Korean J Parasitol. 2020. PMID: 32615735 Free PMC article.
-
Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.J Mol Med (Berl). 2012 Nov;90(11):1237-45. doi: 10.1007/s00109-012-0906-z. Epub 2012 May 11. J Mol Med (Berl). 2012. PMID: 22577036 Review.
-
Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+ PD-L1+ phenotype in prostate cancer.Oncoimmunology. 2014 Dec 13;3(9):e955331. doi: 10.4161/21624011.2014.955331. eCollection 2014 Oct. Oncoimmunology. 2014. PMID: 25941611 Free PMC article.
-
Macrophages promote tumour growth and liver metastasis in an orthotopic syngeneic mouse model of colon cancer.Int J Colorectal Dis. 2013 Oct;28(10):1337-49. doi: 10.1007/s00384-013-1703-z. Epub 2013 May 9. Int J Colorectal Dis. 2013. PMID: 23657400
-
Transcriptomic Profiling of Breast Cancer Cells Induced by Tumor-Associated Macrophages Generates a Robust Prognostic Gene Signature.Cancers (Basel). 2022 Oct 31;14(21):5364. doi: 10.3390/cancers14215364. Cancers (Basel). 2022. PMID: 36358783 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
