Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Oct;8(14):2235-45.
doi: 10.1517/14656566.8.14.2235.

The pharmacogenetics of analgesia

Ulrike M Stamer  1 , Frank Stüber
Affiliations
Review

The pharmacogenetics of analgesia

Ulrike M Stamer et al. Expert Opin Pharmacother. 2007 Oct.

Abstract

Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify associations between an individual's genetic profile and drug response (pharmacogenetics). Polymorphisms of the cytochrome P450 enzymes influence analgesic efficacy of codeine, tramadol and tricyclic antidepressants (CYP2D6). Blood levels of some NSAIDs are dependent on CYP2C9 activity, whereas opioid-receptor polymorphisms are discussed for differences in opioid mediated analgesia and side effects. Pharmacogenetics as a diagnostic tool has the potential to improve patient therapy and care, and it is hoped that pharmacogenetics will individualise drug treatment to a greater extent in the near future.

PubMed Disclaimer

Similar articles

  • [Genetics, pain and analgesia].
    Stamer U, Bayerer B, Stüber F. Stamer U, et al. Anaesthesist. 2006 Jul;55(7):746-52. doi: 10.1007/s00101-006-1017-4. Anaesthesist. 2006. PMID: 16625360 Review. German.
  • Personalized therapy in pain management: where do we stand?
    Stamer UM, Zhang L, Stüber F. Stamer UM, et al. Pharmacogenomics. 2010 Jun;11(6):843-64. doi: 10.2217/pgs.10.47. Pharmacogenomics. 2010. PMID: 20504256 Review.
  • Pharmacogenetics in Pain Treatment.
    Peiró AM. Peiró AM. Adv Pharmacol. 2018;83:247-273. doi: 10.1016/bs.apha.2018.04.004. Epub 2018 May 18. Adv Pharmacol. 2018. PMID: 29801577 Review.
  • Genetic factors in pain and its treatment.
    Stamer UM, Stüber F. Stamer UM, et al. Curr Opin Anaesthesiol. 2007 Oct;20(5):478-84. doi: 10.1097/ACO.0b013e3282ef6b2c. Curr Opin Anaesthesiol. 2007. PMID: 17873601 Review.
  • Pharmacogenetics in palliative care.
    Kleine-Brueggeney M, Musshoff F, Stuber F, Stamer UM. Kleine-Brueggeney M, et al. Forensic Sci Int. 2010 Dec 15;203(1-3):63-70. doi: 10.1016/j.forsciint.2010.07.003. Epub 2010 Aug 14. Forensic Sci Int. 2010. PMID: 20709477 Review.
See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources