Alcohol-induced stress in painful alcoholic neuropathy
- PMID: 18093169
- DOI: 10.1111/j.1460-9568.2007.05987.x
Alcohol-induced stress in painful alcoholic neuropathy
Abstract
Chronic alcohol consumption induces a painful small-fiber peripheral neuropathy, the severity of which increases during alcohol withdrawal. Chronic alcohol consumption also produces a sustained increase in stress hormones, epinephrine and corticosterone, that is exacerbated during alcohol withdrawal. We report that adrenal medullectomy and administration of a glucocorticoid receptor antagonist, mifepristone (RU 38486), both prevented and reversed a model of painful peripheral neuropathy in alcohol binge-drinking rats. Chronic administration of stress levels of epinephrine to rats that had undergone adrenal medullectomy and were being fed the alcohol diet reconstituted this phenotype. Intrathecal administration of oligodeoxynucleotides antisense to the beta(2)-adrenergic- or glucocorticoid-receptor also prevented and reversed the pro-nociceptive effects of ethanol. Our results suggest a convergence of the effects of mediators of the hypothalamic-pituitary- and sympathoadrenal-stress axes on sensory neurons in the induction and maintenance of alcohol-induced painful peripheral neuropathy.
Similar articles
-
Estrogen regulates adrenal medullary function producing sexual dimorphism in nociceptive threshold and beta-adrenergic receptor-mediated hyperalgesia in the rat.Eur J Neurosci. 2005 Jun;21(12):3379-86. doi: 10.1111/j.1460-9568.2005.04158.x. Eur J Neurosci. 2005. PMID: 16026475
-
Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy.Pain. 2009 Sep;145(1-2):129-35. doi: 10.1016/j.pain.2009.05.028. Epub 2009 Jun 21. Pain. 2009. PMID: 19541419
-
Independent contributions of alcohol and stress axis hormones to painful peripheral neuropathy.Neuroscience. 2013 Jan 3;228:409-17. doi: 10.1016/j.neuroscience.2012.10.052. Epub 2012 Nov 2. Neuroscience. 2013. PMID: 23128028 Free PMC article.
-
Alcoholic neuropathy: possible mechanisms and future treatment possibilities.Br J Clin Pharmacol. 2012 Mar;73(3):348-62. doi: 10.1111/j.1365-2125.2011.04111.x. Br J Clin Pharmacol. 2012. PMID: 21988193 Free PMC article. Review.
-
Exploring the Therapeutic Potential of Targeting Purinergic and Orexinergic Receptors in Alcoholic Neuropathy.Neurotox Res. 2022 Apr;40(2):646-669. doi: 10.1007/s12640-022-00477-8. Epub 2022 Jan 26. Neurotox Res. 2022. PMID: 35080764 Review.
Cited by
-
Neurobiological aspects of pain in the context of alcohol use disorder.Int Rev Neurobiol. 2021;157:1-29. doi: 10.1016/bs.irn.2020.09.001. Epub 2020 Oct 6. Int Rev Neurobiol. 2021. PMID: 33648668 Free PMC article.
-
Unpredictable stress delays recovery from exercise-induced muscle pain: contribution of the sympathoadrenal axis.Pain Rep. 2019 Sep 18;4(5):e782. doi: 10.1097/PR9.0000000000000782. eCollection 2019 Sep-Oct. Pain Rep. 2019. PMID: 31875187 Free PMC article.
-
Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress.Pain. 2020 Apr;161(4):865-874. doi: 10.1097/j.pain.0000000000001798. Pain. 2020. PMID: 31917777 Free PMC article.
-
Neuropeptide and cytokine regulation of pain in the context of substance use disorders.Neuropharmacology. 2020 Sep 1;174:108153. doi: 10.1016/j.neuropharm.2020.108153. Epub 2020 May 26. Neuropharmacology. 2020. PMID: 32470337 Free PMC article. Review.
-
A small molecule PKCε inhibitor reduces hyperalgesia induced by paclitaxel or opioid withdrawal.JCI Insight. 2025 Apr 22;10(8):e186805. doi: 10.1172/jci.insight.186805. eCollection 2025 Apr 22. JCI Insight. 2025. PMID: 40260913 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
