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Review
. 2009 Oct;10(14):2269-77.
doi: 10.1517/14656560903120907.

Antiangiogenic drugs in ovarian cancer

Affiliations
Review

Antiangiogenic drugs in ovarian cancer

Maurie Markman. Expert Opin Pharmacother. 2009 Oct.

Abstract

Background: There is a critical need to develop effective new strategies for the management of patients with advanced epithelial ovarian cancer.

Objective: The purpose of this manuscript is to discuss the rationale for, and initial clinical results of, attempts to interfere with the process of tumor angiogenesis as a novel treatment paradigm in ovarian cancer.

Results/conclusion: Phase II clinical trial data provide strong support for the suggestion that antiangiogenic agents have the potential to play a major therapeutic role in this difficult malignancy. It is reasonable to acknowledge that the pending results of several ongoing evidence-based randomized Phase III trials that directly explore the clinical utility of this strategy may substantially alter the current standard management approaches in advanced ovarian cancer.

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