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. 2011 Jan 4;104(1):178-80.
doi: 10.1038/sj.bjc.6605989. Epub 2010 Nov 16.

Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia

D Bzhalava  1 , F Bray, H Storm, J Dillner
Affiliations

Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia

D Bzhalava et al. Br J Cancer. .

Abstract

Background: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.

Methods: To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.

Results: The overall cancer incidence was increased among patients diagnosed with MCC compared with the general population in these countries (79 secondary cancers total, Standardized Incidence Ratio (SIR) 1.38 (95% confidence interval (CI): 1.10-1.72); 49 secondary cancer in females, SIR 1.7 (95% CI: 1.29-2.25); 30 secondary cancers in males and SIR 1.05 (95% CI: 0.73-1.5)). There were significantly increased incidence ratios for non-melanoma skin cancers (34 secondary cancers, SIR 8.35 (95% CI: 5.97-11.68)), melanoma of skin (6 secondary cancers, SIR 4.29 (95% CI: 1.93-9.56)) and laryngeal cancer (2 secondary cancers, SIR 9.51 (95% CI: 2.38-38)). The SIRs for these three cancer sites were also elevated on restricting the follow-up to cancers occurring at least one year after MCC diagnosis.

Conclusions: Patients diagnosed with MCC are at increased risk of a second cancer, particularly, other skin cancers. Conceivable explanations include the impact of increased surveillance of the skin and shared causative factors, for example, ultraviolet light exposure or MCC polyomavirus infection.

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References

    1. Becker J, Houben R, Ugurel S, Trefzer U, Pfohler C, Schrama D (2009) MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol 129: 248–250 - PubMed
    1. Duncavage E, Zehnbauer BA, Pfeifer JD (2009) Prevalence of merkel cell polyomavirus in merkel cell carcinoma. Mod Pathol 22: 516–521 - PubMed
    1. Feng H, Shuda M, Chang Y, Moore PS (2008) Clonal integration of a polyomavirus in human merkel cell carcinoma. Science 319: 1096–1100 - PMC - PubMed
    1. Howard R, Dores GM, Curtis RE, Anderson WF, Travis LB (2006) Merkel cell carcinoma and multiple primary cancers. Cancer Epidemiol Biomarkers Prev 15: 1545–1549 - PubMed
    1. Hussain S, Sundquist J, Hemminki K (2010) Incidence trends of squamous cell and rare skin cancers in the swedish national cancer registry point to calendar year and age-dependent increases. J Invest Dermatol 130(5): 1323–1328 - PubMed