Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy
- PMID: 21118710
- DOI: 10.1016/j.neuroscience.2010.11.046
Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy
Abstract
Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and l-serine concentration were examined. Effects of l-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the l-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of l-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of l-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived l-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
Similar articles
-
Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat.Neurosci Lett. 2006 Sep 11;405(1-2):62-7. doi: 10.1016/j.neulet.2006.06.043. Epub 2006 Jul 18. Neurosci Lett. 2006. PMID: 16854522
-
Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in rats.Spine (Phila Pa 1976). 2008 May 20;33(12):1344-51. doi: 10.1097/BRS.0b013e3181733188. Spine (Phila Pa 1976). 2008. PMID: 18496347
-
Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy.Eur J Cancer. 2009 Jan;45(1):154-63. doi: 10.1016/j.ejca.2008.10.004. Epub 2008 Nov 20. Eur J Cancer. 2009. PMID: 19027286
-
[Role of Transient Receptor Potential Channels in Paclitaxel- and Oxaliplatin-induced Peripheral Neuropathy].Yakugaku Zasshi. 2016;136(2):287-96. doi: 10.1248/yakushi.15-00214. Yakugaku Zasshi. 2016. PMID: 26831807 Review. Japanese.
-
Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?Neurosci Lett. 2015 Jun 2;596:90-107. doi: 10.1016/j.neulet.2014.10.014. Epub 2014 Oct 22. Neurosci Lett. 2015. PMID: 25459280 Review.
Cited by
-
Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients.Front Mol Biosci. 2022 Oct 14;9:1015746. doi: 10.3389/fmolb.2022.1015746. eCollection 2022. Front Mol Biosci. 2022. PMID: 36310587 Free PMC article. Review.
-
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.J Nutr. 2020 Sep 1;150(9):2278-2286. doi: 10.1093/jn/nxaa156. J Nutr. 2020. PMID: 32520991 Free PMC article. Clinical Trial.
-
Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.Neuron. 2017 Oct 11;96(2):373-386.e6. doi: 10.1016/j.neuron.2017.09.034. Neuron. 2017. PMID: 29024661 Free PMC article.
-
Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1.Neurology. 2019 Jan 22;92(4):e359-e370. doi: 10.1212/WNL.0000000000006811. Epub 2019 Jan 9. Neurology. 2019. PMID: 30626650 Free PMC article. Clinical Trial.
-
Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy.FASEB J. 2015 Nov;29(11):4461-72. doi: 10.1096/fj.15-272567. Epub 2015 Jul 21. FASEB J. 2015. PMID: 26198449 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical