Histone deacetylases as regulators of inflammation and immunity
- PMID: 21570914
- DOI: 10.1016/j.it.2011.04.001
Histone deacetylases as regulators of inflammation and immunity
Abstract
Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular growth arrest, differentiation and/or apoptosis, and some are used clinically as anticancer drugs. In animal models, HDAC inhibitors are therapeutic for several inflammatory diseases, but exacerbate atherosclerosis and compromise host defence. Loss of HDAC function has also been linked to chronic lung diseases in humans. These contrasting effects might reflect distinct roles for individual HDACs in immune responses. Here, we review the current understanding of innate and adaptive immune pathways that are regulated by classical HDAC enzymes. The objective is to provide a rationale for targeting (or not targeting) individual HDAC enzymes with inhibitors for future immune-related applications.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Similar articles
-
Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis.Cardiovasc Res. 2011 Jun 1;90(3):413-20. doi: 10.1093/cvr/cvr003. Epub 2011 Jan 13. Cardiovasc Res. 2011. PMID: 21233251 Review.
-
HDAC inhibitors for the treatment of cancer.Curr Opin Investig Drugs. 2003 Dec;4(12):1422-7. Curr Opin Investig Drugs. 2003. PMID: 14763127 Review.
-
Epigenetic regulation of airway inflammation.Curr Opin Immunol. 2007 Dec;19(6):694-700. doi: 10.1016/j.coi.2007.07.016. Epub 2007 Aug 27. Curr Opin Immunol. 2007. PMID: 17720468 Review.
-
Function of histone deacetylase inhibitors in inflammation.Crit Rev Immunol. 2011;31(3):233-63. doi: 10.1615/critrevimmunol.v31.i3.40. Crit Rev Immunol. 2011. PMID: 21740352 Review.
-
Targeting histone deacetylases for the treatment of cancer and inflammatory diseases.J Cell Physiol. 2006 Dec;209(3):611-6. doi: 10.1002/jcp.20781. J Cell Physiol. 2006. PMID: 17001696 Review.
Cited by
-
New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries.Front Immunol. 2021 Feb 23;12:622064. doi: 10.3389/fimmu.2021.622064. eCollection 2021. Front Immunol. 2021. PMID: 33708214 Free PMC article. Review.
-
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.Mol Ther. 2013 Apr;21(4):887-94. doi: 10.1038/mt.2012.265. Epub 2013 Jan 8. Mol Ther. 2013. PMID: 23295947 Free PMC article.
-
The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives.Food Sci Biotechnol. 2023 Aug 28;33(2):275-285. doi: 10.1007/s10068-023-01414-x. eCollection 2024 Jan. Food Sci Biotechnol. 2023. PMID: 38222911 Free PMC article. Review.
-
Short-chain fatty acids are potential goalkeepers of atherosclerosis.Front Pharmacol. 2023 Nov 13;14:1271001. doi: 10.3389/fphar.2023.1271001. eCollection 2023. Front Pharmacol. 2023. PMID: 38027009 Free PMC article. Review.
-
Antibiotics Modulate Intestinal Regeneration.Biology (Basel). 2021 Mar 19;10(3):236. doi: 10.3390/biology10030236. Biology (Basel). 2021. PMID: 33808600 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources