Histone deacetylases as regulators of inflammation and immunity
- PMID: 21570914
- DOI: 10.1016/j.it.2011.04.001
Histone deacetylases as regulators of inflammation and immunity
Abstract
Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular growth arrest, differentiation and/or apoptosis, and some are used clinically as anticancer drugs. In animal models, HDAC inhibitors are therapeutic for several inflammatory diseases, but exacerbate atherosclerosis and compromise host defence. Loss of HDAC function has also been linked to chronic lung diseases in humans. These contrasting effects might reflect distinct roles for individual HDACs in immune responses. Here, we review the current understanding of innate and adaptive immune pathways that are regulated by classical HDAC enzymes. The objective is to provide a rationale for targeting (or not targeting) individual HDAC enzymes with inhibitors for future immune-related applications.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Similar articles
-
Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis.Cardiovasc Res. 2011 Jun 1;90(3):413-20. doi: 10.1093/cvr/cvr003. Epub 2011 Jan 13. Cardiovasc Res. 2011. PMID: 21233251 Review.
-
HDAC inhibitors for the treatment of cancer.Curr Opin Investig Drugs. 2003 Dec;4(12):1422-7. Curr Opin Investig Drugs. 2003. PMID: 14763127 Review.
-
Epigenetic regulation of airway inflammation.Curr Opin Immunol. 2007 Dec;19(6):694-700. doi: 10.1016/j.coi.2007.07.016. Epub 2007 Aug 27. Curr Opin Immunol. 2007. PMID: 17720468 Review.
-
Function of histone deacetylase inhibitors in inflammation.Crit Rev Immunol. 2011;31(3):233-63. doi: 10.1615/critrevimmunol.v31.i3.40. Crit Rev Immunol. 2011. PMID: 21740352 Review.
-
Targeting histone deacetylases for the treatment of cancer and inflammatory diseases.J Cell Physiol. 2006 Dec;209(3):611-6. doi: 10.1002/jcp.20781. J Cell Physiol. 2006. PMID: 17001696 Review.
Cited by
-
Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes.J Immunother. 2013 Jan;36(1):3-10. doi: 10.1097/CJI.0b013e3182791234. J Immunother. 2013. PMID: 23211626 Free PMC article.
-
Up-regulation of HDACs, a harbinger of uraemic endothelial dysfunction, is prevented by defibrotide.J Cell Mol Med. 2020 Jan;24(2):1713-1723. doi: 10.1111/jcmm.14865. Epub 2019 Nov 28. J Cell Mol Med. 2020. PMID: 31782253 Free PMC article.
-
NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila.Dev Cell. 2019 Jun 3;49(5):802-810.e6. doi: 10.1016/j.devcel.2019.04.009. Epub 2019 May 9. Dev Cell. 2019. PMID: 31080057 Free PMC article.
-
New approaches to manipulating the epigenome.Dialogues Clin Neurosci. 2014 Sep;16(3):345-57. doi: 10.31887/DCNS.2014.16.3/jday. Dialogues Clin Neurosci. 2014. PMID: 25364285 Free PMC article. Review.
-
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.PLoS Pathog. 2015 Sep 17;11(9):e1005142. doi: 10.1371/journal.ppat.1005142. eCollection 2015 Sep. PLoS Pathog. 2015. PMID: 26379282 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources