The recent understanding of the neurotrophin's role in skeletal muscle adaptation
- PMID: 21960735
- PMCID: PMC3179880
- DOI: 10.1155/2011/201696
The recent understanding of the neurotrophin's role in skeletal muscle adaptation
Abstract
This paper summarizes the various effects of neurotrophins in skeletal muscle and how these proteins act as potential regulators of the maintenance, function, and regeneration of skeletal muscle fibers. Increasing evidence suggests that this family of neurotrophic factors influence not only the survival and function of innervating motoneurons but also the development and differentiation of myoblasts and muscle fibers. Muscle contractions (e.g., exercise) produce BDNF mRNA and protein in skeletal muscle, and the BDNF seems to play a role in enhancing glucose metabolism and may act for myokine to improve various brain disorders (e.g., Alzheimer's disease and major depression). In adults with neuromuscular disorders, variations in neurotrophin expression are found, and the role of neurotrophins under such conditions is beginning to be elucidated. This paper provides a basis for a better understanding of the role of these factors under such pathological conditions and for treatment of human neuromuscular disease.
Figures


Similar articles
-
The role of neurotrophins in muscle under physiological and pathological conditions.Muscle Nerve. 2006 Apr;33(4):462-76. doi: 10.1002/mus.20444. Muscle Nerve. 2006. PMID: 16228973 Review.
-
Autocrine and immune cell-derived BDNF in human skeletal muscle: implications for myogenesis and tissue regeneration.J Pathol. 2013 Oct;231(2):190-8. doi: 10.1002/path.4228. Epub 2013 Aug 12. J Pathol. 2013. PMID: 23775641
-
Expression of midkine in regenerating skeletal muscle fibers and cultured myoblasts of human skeletal muscle.Eur Neurol. 2002;47(1):20-5. doi: 10.1159/000047942. Eur Neurol. 2002. PMID: 11803188
-
A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy.Brain Res. 2001 Jul 13;907(1-2):1-19. doi: 10.1016/s0006-8993(01)02288-0. Brain Res. 2001. PMID: 11430880
-
[The role of NGF and BDNF in mature brain activity regulation].Zh Vyssh Nerv Deiat Im I P Pavlova. 2014 Mar-Apr;64(2):137-46. Zh Vyssh Nerv Deiat Im I P Pavlova. 2014. PMID: 25713864 Review. Russian.
Cited by
-
Ectopic uterine tissue as a chronic pain generator.Neuroscience. 2012 Dec 6;225:269-82. doi: 10.1016/j.neuroscience.2012.08.033. Epub 2012 Aug 23. Neuroscience. 2012. PMID: 22922120 Free PMC article.
-
The Role of Crosstalk between Adipose Cells and Myocytes in the Pathogenesis of Sarcopenic Obesity in the Elderly.Cells. 2022 Oct 25;11(21):3361. doi: 10.3390/cells11213361. Cells. 2022. PMID: 36359757 Free PMC article. Review.
-
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle.Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16111-16120. doi: 10.1073/pnas.1900544116. Epub 2019 Jul 18. Proc Natl Acad Sci U S A. 2019. PMID: 31320589 Free PMC article.
-
Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction.Cell Biosci. 2023 Mar 16;13(1):56. doi: 10.1186/s13578-023-01009-3. Cell Biosci. 2023. PMID: 36927578 Free PMC article. Review.
-
A new protein curbs the hypertrophic effect of myostatin inhibition, adding remarkable endurance to motor performance in mice.PLoS One. 2020 Mar 11;15(3):e0228653. doi: 10.1371/journal.pone.0228653. eCollection 2020. PLoS One. 2020. PMID: 32160187 Free PMC article.
References
-
- Oppenheim RW. Cell death during development of the nervous system. Annual Review of Neuroscience. 1991;14:453–501. - PubMed
-
- Griesbeck O, Parsadanian AS, Sendtner M, Thoenen H. Expression of neurotrophins in skeletal muscle: quantitative comparison and significance for motoneuron survival and maintenance of function. Journal of Neuroscience Research. 1995;42(1):21–33. - PubMed
-
- Chevrel G, Hohlfeld R, Sendtner M. The role of neurotrophins in muscle under physiological and pathological conditions. Muscle and Nerve. 2006;33(4):462–476. - PubMed
-
- Pitts EV, Potluri S, Hess DM, Balice-Gordon RJ. Neurotrophin and Trk-mediated signaling in the neuromuscular system. International Anesthesiology Clinics. 2006;44(2):21–76. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical