Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Jun;9(2):196-8.
doi: 10.1007/s13181-013-0287-x.

Recurrent seizures and serotonin syndrome following "2C-I" ingestion

Adam Bosak  1 , Frank LoVecchio, Michael Levine
Affiliations
Case Reports

Recurrent seizures and serotonin syndrome following "2C-I" ingestion

Adam Bosak et al. J Med Toxicol. 2013 Jun.

Abstract

The phenethylamines, including 2, 5 dimethoxy-4-iodophenethylamine, commonly referred to as 2C-I, have recently emerged as a new class of designer drugs. Cases of toxicity from these drugs are not well described in the literature. This case report describes a 19 year-old male who insufflated 2C-I. Following the ingestion, the patient developed recurrent seizures, and was taken to the emergency department, where he was noted to be hyperadrenergic and had recurrent seizures. The patient was diagnosed with serotonin syndrome and experienced prolonged respiratory failure, although he ultimately made a full recovery. Comprehensive drug testing revealed the presence of 2C-I. The pharmacologic properties of 2C-I are also discussed.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Chemical structure of 2,5 dimethoxy-4-iodophenethylamine
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Haroz R, Greenberg MI. Emerging drugs of abuse. Med Clin N Am. 2005;89:1259–76. doi: 10.1016/j.mcna.2005.06.008. - DOI - PubMed
    1. Andreasen MF, Telving R, Birkler RI, et al. A fatal poisoning involving Bromo-Dragonfly. Forensic Sci Int. 2009;183:91–6. doi: 10.1016/j.forsciint.2008.11.001. - DOI - PubMed
    1. Theobald DS, Pütz M, Schneider E, et al. New designer drug 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I): studies on its metabolism and toxicological detection in rat urine using gas chromatographic-mass spectrometric and capillary electrophoretic/mass spectrometric techniques. J Mass Spectrom. 2006;41:872–86. doi: 10.1002/jms.1045. - DOI - PubMed
    1. Johnson MP, Mathis CA, Shuligin AT, et al. [125I]-2-(2, 5-Dimethoxy-4-iodophenyl)aminoethane ([125]-2C-I) as a label for the 5HT2 receptor in rat frontal cortex. Pharmacol Biochem Behav. 1990;35:211–7. doi: 10.1016/0091-3057(90)90228-A. - DOI - PubMed
    1. Castillo AC, Villalobos C, Moya PR, et al. Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5HT2A and 5HT2C receptors. Br J Pharmacol. 2002;136:510–9. doi: 10.1038/sj.bjp.0704747. - DOI - PMC - PubMed

Publication types

MeSH terms