New treatments for osteoarthritis
- PMID: 23425965
- DOI: 10.1097/BOR.0b013e32835f69b4
New treatments for osteoarthritis
Abstract
Purpose of review: To review new data on pharmacologic treatment of osteoarthritis for the years 2011-2012.
Recent findings: Duloxetine was approved for the treatment of chronic knee pain due to osteoarthritis and has been conditionally recommended by the American College of Rheumatology. Strontium ranelate was found to significantly decrease the rate of decline in joint space width as well as improve pain scores compared with placebo in a large multicenter study in patients with symptomatic knee osteoarthritis. Nerve growth factor (NGF) monoclonal antibody therapy has shown much promise with regard to improvement in pain; however, clinical development studies were stopped out of concern for adverse events in 2010. After a review by the Food and Drug Administration, this hold may be lifted and further studies may resume in 2013. The biologic agents interleukin-1 receptor antagonist and antitumor necrosis factor antibodies have not been shown to be efficacious nor to alter the course of osteoarthritis. Much research surrounding intra-articular injections of platelet-rich plasma (PRP) has not produced clear evidence that this therapy is efficacious in osteoarthritis. There are presently studies using mesenchymal stem cell therapy for osteoarthritis.
Summary: Duloxetine, strontium ranelate, and NGF antibodies are promising therapies for symptomatic osteoarthritis. At this time, MSCs and PRP require more investigation.
Similar articles
-
Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis.Knee Surg Sports Traumatol Arthrosc. 2018 Nov;26(11):3342-3350. doi: 10.1007/s00167-018-4883-9. Epub 2018 Mar 6. Knee Surg Sports Traumatol Arthrosc. 2018. PMID: 29511819 Clinical Trial.
-
Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis.Arthroscopy. 2011 Nov;27(11):1490-501. doi: 10.1016/j.arthro.2011.05.011. Epub 2011 Aug 10. Arthroscopy. 2011. PMID: 21831567 Clinical Trial.
-
Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis.Knee. 2012 Dec;19(6):902-7. doi: 10.1016/j.knee.2012.04.001. Epub 2012 May 14. Knee. 2012. PMID: 22583627 Clinical Trial.
-
Biologic Therapies for the Treatment of Knee Osteoarthritis.J Arthroplasty. 2019 Apr;34(4):801-813. doi: 10.1016/j.arth.2018.12.001. Epub 2018 Dec 17. J Arthroplasty. 2019. PMID: 30612835
-
Biologic Therapy in Chronic Pain Management: a Review of the Clinical Data and Future Investigations.Curr Pain Headache Rep. 2021 Mar 24;25(5):30. doi: 10.1007/s11916-021-00947-2. Curr Pain Headache Rep. 2021. PMID: 33761016 Review.
Cited by
-
Re-irradiation for osteoarthritis-retrospective analysis of 217 joints.Strahlenther Onkol. 2019 Dec;195(12):1060-1067. doi: 10.1007/s00066-019-01500-2. Epub 2019 Jul 25. Strahlenther Onkol. 2019. PMID: 31346673 English.
-
Translation, cross-cultural adaptation and validation of the Osteoarthritis Quality of Life (OAQoL) questionnaire for use in Portugal.Rheumatol Int. 2019 Apr;39(4):715-722. doi: 10.1007/s00296-018-4197-8. Epub 2018 Nov 10. Rheumatol Int. 2019. PMID: 30415453
-
The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis.Clin Interv Aging. 2018 Jan 4;13:73-79. doi: 10.2147/CIA.S147757. eCollection 2018. Clin Interv Aging. 2018. PMID: 29379278 Free PMC article. Clinical Trial.
-
An Updated Systematic Review and Meta-analysis of Duloxetine for Knee Osteoarthritis Pain.Clin J Pain. 2021 Nov 1;37(11):852-862. doi: 10.1097/AJP.0000000000000975. Clin J Pain. 2021. PMID: 34483232 Free PMC article.
-
Future directions for the management of pain in osteoarthritis.Int J Clin Rheumtol. 2014 Apr;9(2):197-276. doi: 10.2217/ijr.14.10. Int J Clin Rheumtol. 2014. PMID: 25018771 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
