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Review
. 2013 Jun;9(2):172-8.
doi: 10.1007/s13181-013-0295-x.

2C or not 2C: phenethylamine designer drug review

Be Vang Dean  1 , Samuel J Stellpflug, Aaron M Burnett, Kristin M Engebretsen
Affiliations
Review

2C or not 2C: phenethylamine designer drug review

Be Vang Dean et al. J Med Toxicol. 2013 Jun.

Abstract

New groups of synthetic "designer drugs" have increased in popularity over the past several years. These products mimic the euphoric effects of other well-known illicit drugs but are advertised as "legal" highs and are sold over the internet, at raves and night clubs, and in head shops. The 2C series drugs are ring-substituted phenethylamines that belong to a group of designer agents similar in structure to 3,4-methylenedioxy-N-methylamphetamine (MDMA, Ecstasy). Understanding the pharmacology and toxicology of these agents is essential in order to provide the best medical care for these patients. This review focuses on the pharmacology, pharmacokinetics, clinical effects, and treatment of 2C drug intoxication based on available published literature. Multiple names under which 2C drugs are sold were identified and tabulated. Common features identified in patients intoxicated with 2Cs included hallucinations, agitation, aggression, violence, dysphoria, hypertension, tachycardia, seizures, and hyperthermia. Patients may exhibit sympathomimetic symptoms or symptoms consistent with serotonin toxicity, but an excited delirium presentation seems to be consistent amongst deaths attributed to 2C drugs; at least five deaths have been reported in the literature in patients intoxicated with 2C drugs. 2C drugs are a group of designer intoxicants, many of which are marketed as legal, but may carry risks that consumers are unaware of. These drugs may be characterized by either serotonergic toxicity or a sympathomimetic toxidrome, but a presentation consistent with excited delirium is consistent amongst the reported 2C-related deaths. Treatment of 2C intoxication is primarily supportive, but immediate action is required in the context of excited delirium, hyperthermia, and seizure activity.

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Figures

Fig. 1
Fig. 1
General structure of 2C with labeled positions [3, 4]
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References

    1. Drug Enforcement Administration [webpage on the Internet]. Drugs of abuse, 2011 edition. Washington, DC: Drug Enforcement Administration [updated 2012 Jun 20]. Available from: http://www.justice.gov/dea/docs/drugs_of_abuse_2011.pdf. Accessed 12 Feb 2013
    1. Haroz RH, Greenberg MI. New drugs of abuse in North America. Clin Lab Med. 2006;26:147–164. doi: 10.1016/j.cll.2006.01.008. - DOI - PubMed
    1. Shulgin AT, Shulgin A. PIHKAL: a chemical love story. Berkeley: Transform Press; 1991.
    1. Erowid[webpage on the Internet]. Erowid 2C-B Vault Basics. Grass Valley, CA; Erowid [updated 2011 Feb 11]. Available from: http://www.erowid.org/chemicals/2cb/2cb_basics.shtml. Accessed 12 Feb 2013
    1. Wikipedia [webpage on the Internet]. 2C (psychedelics). San Francisco, CA; Wikipedia Foundation, Inc. [updated 2012 Nov 27]. Available from: http://en.wikipedia.org/wiki/2C_%28psychedelics%29. Accessed 12 Feb 2013

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