Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Aug;34(8):458-69.
doi: 10.1016/j.tips.2013.05.006. Epub 2013 Jun 13.

Understanding platinum-induced ototoxicity

Thorsten Langer  1 , Antoinette am Zehnhoff-Dinnesen, Susanne Radtke, Johannes Meitert, Oliver Zolk
Affiliations
Review

Understanding platinum-induced ototoxicity

Thorsten Langer et al. Trends Pharmacol Sci. 2013 Aug.

Abstract

Childhood cancer survival rates are now nearly 80% in more developed European countries because of improved therapies and better supportive care. Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the antitumor efficacy of cisplatin and carboplatin comes at the cost of ototoxicity, which affects at least 60% of pediatric patients. Although ototoxicity is not life threatening, it can have debilitating effects on patients' quality of life. Recently, many initiatives have been launched with the ultimate goal of reducing cisplatin and high-dose carboplatin ototoxicity without compromising antitumor efficacy. This review addresses the incidence of platinum ototoxicity and its clinical presentation, time course, and early diagnostic evaluation. Genetic and non-genetic risk factors for platinum-associated ototoxicity, and their predictive value, are discussed. Recent developments in the prevention of platinum ototoxicity are also summarized.

Keywords: adverse effects; high frequency audiometry; organoplatinum compounds; pharmacogenetics; prevention; risk factors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles