Altered brain-gut axis in autism: comorbidity or causative mechanisms?
- PMID: 25145752
- DOI: 10.1002/bies.201400075
Altered brain-gut axis in autism: comorbidity or causative mechanisms?
Abstract
The concept that alterated communications between the gut microbiome and the brain may play an important role in human brain disorders has recently received considerable attention. This is the result of provocative preclinical and some clinical evidence supporting early hypotheses about such communication in health and disease. Gastrointestinal symptoms are a common comorbidity in patients with autism spectrum disorders (ASD), even though the underlying mechanisms are largely unknown. In addition, alteration in the composition and metabolic products of the gut microbiome has long been implicated as a possible causative mechanism contributing to ASD pathophysiology, and this hypothesis has been supported by several recently published evidence from rodent models of autism induced by prenatal insults to the mother. Recent evidence in one such model involving maternal infection, that is characterized by alterations in behavior, gut physiology, microbial composition, and related metabolite profile, suggests a possible benefit of probiotic treatment on several of the observed abnormal behaviors.
Keywords: brain gut interactions; gut microbiome; intestinal permeability; neurodevelopment disorder.
© 2014 WILEY Periodicals, Inc.
Similar articles
-
Gastrointestinal microbiota in children with autism in Slovakia.Physiol Behav. 2015 Jan;138:179-87. doi: 10.1016/j.physbeh.2014.10.033. Epub 2014 Nov 6. Physiol Behav. 2015. PMID: 25446201
-
Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters.BMC Psychiatry. 2016 Jun 4;16:183. doi: 10.1186/s12888-016-0887-5. BMC Psychiatry. 2016. PMID: 27260271 Free PMC article. Clinical Trial.
-
Gut-Brain Axis and Behavior.Nestle Nutr Inst Workshop Ser. 2017;88:45-53. doi: 10.1159/000461732. Epub 2017 Mar 27. Nestle Nutr Inst Workshop Ser. 2017. PMID: 28346923 Free PMC article. Review.
-
Gut microbiota in autism and mood disorders.World J Gastroenterol. 2016 Jan 7;22(1):361-8. doi: 10.3748/wjg.v22.i1.361. World J Gastroenterol. 2016. PMID: 26755882 Free PMC article. Review.
-
Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet.J Agric Food Chem. 2015 Sep 16;63(36):7885-95. doi: 10.1021/acs.jafc.5b02404. Epub 2015 Sep 1. J Agric Food Chem. 2015. PMID: 26306709 Review.
Cited by
-
Reframing the Teenage Wasteland: Adolescent Microbiota-Gut-Brain Axis.Can J Psychiatry. 2016 Apr;61(4):214-21. doi: 10.1177/0706743716635536. Epub 2016 Feb 24. Can J Psychiatry. 2016. PMID: 27254413 Free PMC article. Review.
-
Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus.Eur J Neurosci. 2016 Nov;44(9):2654-2666. doi: 10.1111/ejn.13291. Epub 2016 Jul 8. Eur J Neurosci. 2016. PMID: 27256072 Free PMC article.
-
Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders.Nutrients. 2022 Sep 24;14(19):3967. doi: 10.3390/nu14193967. Nutrients. 2022. PMID: 36235622 Free PMC article. Review.
-
Signals from the gut microbiota to distant organs in physiology and disease.Nat Med. 2016 Oct;22(10):1079-1089. doi: 10.1038/nm.4185. Epub 2016 Oct 6. Nat Med. 2016. PMID: 27711063 Review.
-
Efficiency of probiotics in elderly patients undergoing orthopedic surgery for postoperative cognitive dysfunction: a study protocol for a multicenter, randomized controlled trial.Trials. 2023 Feb 25;24(1):146. doi: 10.1186/s13063-023-07167-6. Trials. 2023. PMID: 36841790 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
