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. 2015 May;17(3):237-47.
doi: 10.1177/1099800414550394. Epub 2014 Oct 10.

Associations between cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression in patients prior to breast cancer surgery

Sy-Huey Doong  1 , Anand Dhruva  2 , Laura B Dunn  2 , Claudia West  1 , Steven M Paul  1 , Bruce A Cooper  1 , Charles Elboim  3 , Gary Abrams  2 , John D Merriman  1 , Dale J Langford  1 , Heather Leutwyler  1 , Christina Baggott  1 , Kord Kober  1 , Bradley E Aouizerat  4 , Christine Miaskowski  5
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Associations between cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression in patients prior to breast cancer surgery

Sy-Huey Doong et al. Biol Res Nurs. 2015 May.

Abstract

Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of proinflammatory cytokines. The purposes of this study were to determine whether distinct latent classes of patients with breast cancer (n = 398) could be identified based on their experience with this symptom cluster, whether patients in these latent classes differed on demographic and clinical characteristics and whether variations in cytokine genes were associated with latent class membership. Three distinct latent classes were identified: "all low" (61.0%), "low pain and high fatigue" (31.6%), "all high" (7.1%). Compared to patients in the all low class, patients in the all high class were significantly younger, had less education, were more likely to be non-White, had a lower annual income, were more likely to live alone, had a lower functional status, had a higher comorbidity score, and had more advanced disease. Significant associations were found between interleukin 6 (IL6) rs2069845, IL13 rs1295686, and tumor necrosis factor alpha rs18800610 and latent class membership. Findings suggest that variations in pro- and anti-inflammatory cytokine genes are associated with this symptom cluster in breast cancer patients.

Keywords: candidate genes; cytokines; depression; fatigue; interleukin; pain; sleep disturbance; symptom cluster; tumor necrosis factor alpha.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no conflicts of interest with respect to the research, authorship, and/or publication of this article.

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