The gut microbiome and diet in psychiatry: focus on depression
- PMID: 25415497
- DOI: 10.1097/YCO.0000000000000117
The gut microbiome and diet in psychiatry: focus on depression
Abstract
Purpose of review: With depressive disorders the leading source of disability globally, the identification of new targets for prevention and management is imperative. A rapidly emerging field of research suggests that the microbiome-gut-brain axis is of substantial relevance to mood and behaviour. Similarly, unhealthy diet has recently emerged as a significant correlate of and risk factor for depression. This review provides evidence for the gut microbiota as a key factor mediating the link between diet and depressive illness.
Recent findings: The development of new technologies is affording a better understanding of how diet influences gut microbiota composition and activity and how this may, in turn, influence depressive illness. New interventions are also suggesting the possible utility of pre and probiotic formulations and fermented food in influencing mental health.
Summary: Although in its early stages, the emerging field of research focused on the human microbiome suggests an important role for the gut microbiota in influencing brain development, behaviour and mood in humans. The recognition that the gut microbiota interacts bidirectionally with other environmental risk factors, such as diet and stress, suggests promise in the development of interventions targeting the gut microbiota for the prevention and treatment of common mental health disorders.
Similar articles
-
Gut-brain axis: how the microbiome influences anxiety and depression.Trends Neurosci. 2013 May;36(5):305-12. doi: 10.1016/j.tins.2013.01.005. Epub 2013 Feb 4. Trends Neurosci. 2013. PMID: 23384445 Review.
-
Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis.Pediatr Res. 2015 Jan;77(1-2):127-35. doi: 10.1038/pr.2014.161. Epub 2014 Oct 10. Pediatr Res. 2015. PMID: 25303278 Review.
-
Gut microbiome and depression: what we know and what we need to know.Rev Neurosci. 2018 Aug 28;29(6):629-643. doi: 10.1515/revneuro-2017-0072. Rev Neurosci. 2018. PMID: 29397391 Review.
-
Microbiota regulation of the Mammalian gut-brain axis.Adv Appl Microbiol. 2015;91:1-62. doi: 10.1016/bs.aambs.2015.02.001. Epub 2015 Mar 11. Adv Appl Microbiol. 2015. PMID: 25911232 Review.
-
The impact of gut microbiota on brain and behaviour: implications for psychiatry.Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):552-8. doi: 10.1097/MCO.0000000000000221. Curr Opin Clin Nutr Metab Care. 2015. PMID: 26372511 Review.
Cited by
-
Depression and the Aberrant Intestinal Microbiome.Gastroenterol Hepatol (N Y). 2024 Jan;20(1):30-40. Gastroenterol Hepatol (N Y). 2024. PMID: 38405047 Free PMC article.
-
The Influence of Probiotic Supplementation on the Severity of Anxiety and Depressive Symptoms; Function and Composition of Gut Microbiota; and Metabolic, Inflammation, and Oxidative Stress Markers in Patients with Depression-A Study Protocol.Metabolites. 2023 Jan 25;13(2):182. doi: 10.3390/metabo13020182. Metabolites. 2023. PMID: 36837799 Free PMC article.
-
Drugs, Guts, Brains, but Not Rock and Roll: The Need to Consider the Role of Gut Microbiota in Contemporary Mental Health and Wellness of Emerging Adults.Int J Mol Sci. 2022 Jun 14;23(12):6643. doi: 10.3390/ijms23126643. Int J Mol Sci. 2022. PMID: 35743087 Free PMC article. Review.
-
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders.Cells. 2022 Dec 23;12(1):54. doi: 10.3390/cells12010054. Cells. 2022. PMID: 36611848 Free PMC article. Review.
-
The Microbiota-Gut-Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect.Nutrients. 2022 May 16;14(10):2081. doi: 10.3390/nu14102081. Nutrients. 2022. PMID: 35631224 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials