Involvement of the mu-opiate receptor in peripheral analgesia
- PMID: 2557556
- DOI: 10.1016/0306-4522(89)90279-0
Involvement of the mu-opiate receptor in peripheral analgesia
Abstract
The intradermal injection of mu (morphine, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and morphiceptin), kappa (trans-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl) cyclohexyl]benzeneactemide) and delta ([D-Pen2.5]-enkephalin and [D-Ser2]-[Leu]enkephalin-Thr) selective opioid-agonists, by themselves, did not significantly affect the mechanical nociceptive threshold in the hindpaw of the rat. Intradermal injection of mu, but not delta or kappa opioid-agonists, however, produced dose-dependent inhibition of prostaglandin E2-induced hyperalgesia. The analgesic effect of the mu-agonist morphine was dose-dependently antagonized by naloxone and prevented by co-injection of pertussis toxin. Morphine did not, however, alter the hyperalgesia induced by 8-bromo cyclic adenosine monophosphate. We conclude that the analgesic action of opioids on the peripheral terminals of primary afferents is via a binding site with characteristics of the mu-opioid receptor and that this action is mediated by inhibition of the cyclic adenosine monophosphate second messenger system.
Similar articles
-
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.J Pharmacol Exp Ther. 1988 Feb;244(2):456-62. J Pharmacol Exp Ther. 1988. PMID: 2831341
-
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.J Pharmacol Exp Ther. 1989 Mar;248(3):1269-75. J Pharmacol Exp Ther. 1989. PMID: 2539460
-
Peptide opioid antagonist separates peripheral and central opioid antitransit effects.J Pharmacol Exp Ther. 1987 Nov;243(2):492-500. J Pharmacol Exp Ther. 1987. PMID: 2824748
-
Morphine receptors in immunocytes and neurons.Adv Neuroimmunol. 1994;4(2):69-82. doi: 10.1016/s0960-5428(05)80002-6. Adv Neuroimmunol. 1994. PMID: 7952830 Review.
-
The endogenous opioid system and clinical pain management.AACN Clin Issues. 2005 Jul-Sep;16(3):291-301. doi: 10.1097/00044067-200507000-00003. AACN Clin Issues. 2005. PMID: 16082232 Review.
Cited by
-
Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models.J Pharm Bioallied Sci. 2012 Oct;4(4):291-301. doi: 10.4103/0975-7406.103251. J Pharm Bioallied Sci. 2012. PMID: 23248562 Free PMC article.
-
Results of continuous long-term intravenous application of octreotide via an implantable pump system in acromegaly resistant to operative and X-ray therapy.Acta Neurochir (Wien). 1992;117(3-4):160-5. doi: 10.1007/BF01400614. Acta Neurochir (Wien). 1992. PMID: 1414517
-
[Peripheral opioid receptors and their role in postoperative pain management.].Schmerz. 1993 Mar;7(1):4-7. doi: 10.1007/BF02527631. Schmerz. 1993. PMID: 18415412 German.
-
Distribution of functional opioid receptors in human dorsal root ganglion neurons.Pain. 2020 Jul;161(7):1636-1649. doi: 10.1097/j.pain.0000000000001846. Pain. 2020. PMID: 32102022 Free PMC article.
-
Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat.Br J Pharmacol. 1996 Jun;118(3):671-80. doi: 10.1111/j.1476-5381.1996.tb15453.x. Br J Pharmacol. 1996. PMID: 8762093 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials