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Review
. 2015 Jan;20(1):4-9.

Pathophysiology of carpal tunnel syndrome

Moutasem S Aboonq  1
Affiliations
Review

Pathophysiology of carpal tunnel syndrome

Moutasem S Aboonq. Neurosciences (Riyadh). 2015 Jan.

Abstract

Carpal tunnel syndrome (CTS) is the most common median nerve neuropathy, accounting for 90% of all neuropathies. Carpal tunnel syndrome presents in 3.8% of the general population, with a higher prevalence among women. There are several risk factors associated with CTS, including both medical and non medical factors. The pathophysiologic mechanisms involved in the median nerve compression and traction are thought to be complex, and as yet are not fully understood. The present review aimed to provide an overview of the pathophysiology of median nerve neuropathy in the carpal tunnel, and subsequent development of CTS.

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Figures

Figure 1
Figure 1
A schematic presentation for vascular mechanism of carpal tunnel syndrome and median nerve injury. HIF-1α - hypoxia-inducible factor 1α, VEGF - vascular endothelial grown factor
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References

    1. MacDermid JC, Doherty T. Clinical and electrodiagnostic testing of carpal tunnel syndrome: a narrative review. J Orthop Sports Phys Ther. 2004;34:565–588. - PubMed
    1. Dorwart BB. Carpal tunnel syndrome: a review. Semin Arthritis Rheum. 1984;14:134–140. - PubMed
    1. Alfonso C, Jann S, Massa R, Torreggiani A. Diagnosis, treatment and follow-up of the carpal tunnel syndrome: a review. Neurol Sci. 2010;31:243–252. - PubMed
    1. American Academy of Orthopaedic Surgeons Work Group Panel. AAOS Clinical Practice Guideline on the diagnosis of carpal tunnel syndrome. Rosemont (IL): American Academy of Orthopaedic Surgeons; 2007.
    1. Paget J Lectures on surgical pathology. Philadelphia (PA): Lindsay and Blakiston; 1854.

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