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Review
. 2016 Jan;140(1):176-83.
doi: 10.1016/j.ygyno.2015.11.011. Epub 2015 Nov 7.

Chemotherapy-induced peripheral neuropathy: Current status and progress

Jamie R Brewer  1 , Gladys Morrison  2 , M Eileen Dolan  2 , Gini F Fleming  3
Affiliations
Review

Chemotherapy-induced peripheral neuropathy: Current status and progress

Jamie R Brewer et al. Gynecol Oncol. 2016 Jan.

Abstract

As there are increasing numbers of cancer survivors, more attention is being paid to the long term unwanted effects patients may experience as a result of their treatment and the impact these side effects can have on their quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common long-term toxicities from chemotherapy. In this review we will briefly review the clinical presentation, evaluation and management of chemotherapy-induced peripheral neuropathy, with a focus on CIPN related to platinum and taxane agents. We will then discuss current clinical models of peripheral neuropathy and ongoing research to better understand CIPN and develop potential treatment options.

Keywords: Chemotherapy; Neuropathy; Toxicity.

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Figure 1. Potential of iPSC derived models
Recent technological development allows for the development of induced pluripotent stem cells (iPSCs) and differentiation to neurons for drug development, mechanistic evaluation and toxicity testing to ultimately improve health.
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