Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

doi:10.3389/fphar.2015.00234

Review

. 2015 Oct 23:6:234.

doi: 10.3389/fphar.2015.00234. eCollection 2015.

Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

Xiao L Cheng¹, Hong Q Liu², Qi Wang³, Jie G Huo², Xiao N Wang², Peng Cao¹

Affiliations

¹ Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China ; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing, China.
² Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China.
³ Jiangsu Shenlong Pharmaceutical Co., Ltd. Yancheng, China.

PMID: 26557088
PMCID: PMC4615942
DOI: 10.3389/fphar.2015.00234

Review

Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

Xiao L Cheng et al. Front Pharmacol. 2015.

. 2015 Oct 23:6:234.

doi: 10.3389/fphar.2015.00234. eCollection 2015.

Authors

Xiao L Cheng¹, Hong Q Liu², Qi Wang³, Jie G Huo², Xiao N Wang², Peng Cao¹

Affiliations

¹ Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China ; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing, China.
² Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China.
³ Jiangsu Shenlong Pharmaceutical Co., Ltd. Yancheng, China.

PMID: 26557088
PMCID: PMC4615942
DOI: 10.3389/fphar.2015.00234

Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe and dose-limiting side effect of antineoplastic drugs. It can cause sensory, motor and autonomic system dysfunction, and ultimately force patients to discontinue chemotherapy. Until now, little is understood about CIPN and no consistent caring standard is available. Since CIPN is a multifactorial disease, the clinical efficacy of single pharmacological drugs is disappointing, prompting patients to seek alternative treatment options. Complementary and alternative medicines (CAMs), especially herbal medicines, are well known for their multifaceted implications and widely used in human health care. Up to date, several phytochemicals, plant extractions, and herbal formulas have been evaluated for their potential therapeutic benefit of preventing the onset and progression of CIPN in experimental models. Clinical acupuncture has also been shown to improve CIPN symptoms. In this review, we will give an outline of our current knowledge regrading the advanced research of CIPN, the role of CAMs in alleviating CIPN and possible lacunae in research that needs to be addressed.

Keywords: Pathogenesis; acupuncture; chemotherapy-induced peripheral neurotoxicity; complementary and alternative medicine; herbal medicine.

PubMed Disclaimer

Figures

**FIGURE 1**
Summary of the mechanisms of chemotherapy-induced peripheral neurotoxicity (CIPN) and experimental evidence-based applications of complementary and alternative medicines (CAMs) for its prevention or treatment. All the icons in this figure were obtained from http://image.baidu.com.

See this image and copyright information in PMC

Cited by

Huangqi Guizhi Wuwu Decoction can prevent and treat oxaliplatin-induced neuropathic pain by TNFα/IL-1β/IL-6/MAPK/NF-kB pathway.
Li M, Li Z, Ma X, Jin S, Cao Y, Wang X, Zhao J, Wang J, Wang X, Xu J. Li M, et al. Aging (Albany NY). 2022 Jun 27;14(12):5013-5022. doi: 10.18632/aging.203794. Epub 2022 Jun 27. Aging (Albany NY). 2022. PMID: 35759577 Free PMC article.
A Systematic Review of Herbal Medicine for Chemotherapy Induced Peripheral Neuropathy.
Noh H, Yoon SW, Park B. Noh H, et al. Evid Based Complement Alternat Med. 2018 Feb 14;2018:6194184. doi: 10.1155/2018/6194184. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 29636782 Free PMC article.
Liu Jun Zi Tang-A Potential, Multi-Herbal Complementary Therapy for Chemotherapy-Induced Neurotoxicity.
Chiou CT, Wang KC, Yang YC, Huang CL, Yang SH, Kuo YH, Huang NK. Chiou CT, et al. Int J Mol Sci. 2018 Apr 23;19(4):1258. doi: 10.3390/ijms19041258. Int J Mol Sci. 2018. PMID: 29690597 Free PMC article.
The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review.
Nawarathna G, Fakhruddin KS, Shorbagi AISA, Samaranayake LP. Nawarathna G, et al. Gut Microbiome (Camb). 2023 Jun 19;4:e10. doi: 10.1017/gmb.2023.7. eCollection 2023. Gut Microbiome (Camb). 2023. PMID: 39295900 Free PMC article.
Editor's Highlight: Multiparametric Image Analysis of Rat Dorsal Root Ganglion Cultures to Evaluate Peripheral Neuropathy-Inducing Chemotherapeutics.
Guo L, Hamre J 3rd, Eldridge S, Behrsing HP, Cutuli FM, Mussio J, Davis M. Guo L, et al. Toxicol Sci. 2017 Mar 1;156(1):275-288. doi: 10.1093/toxsci/kfw254. Toxicol Sci. 2017. PMID: 28115644 Free PMC article.

See all "Cited by" articles

References

1. Akira S., Takeda K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4 499–511. 10.1038/nri1391 - DOI - PubMed
1. Al Moundhri M. S., Al-Salam S., Al Mahrouqee A., Beegam S., Ali B. H. (2013). The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats. J. Med. Toxicol. 9 25–33. 10.1007/s13181-012-0239-x - DOI - PMC - PubMed
1. Alessandri-Haber N., Dina O. A., Joseph E. K., Reichling D. B., Levine J. D. (2008). Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046–1057. 10.1523/JNEUROSCI.4497-07.2008 - DOI - PMC - PubMed
1. Ameyaw E. O., Woode E., Boakye-Gyasi E., Abotsi W. K., Kyekyeku J. O., Adosraku R. K. (2014). Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 6 172–179. 10.4103/0974-8490.129041 - DOI - PMC - PubMed
1. Anand U., Otto W. R., Anand P. (2010). Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. Mol. Pain 6:82 10.1186/1744-8069-6-82 - DOI - PMC - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Akira S., Takeda K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4 499–511. 10.1038/nri1391 - DOI - PubMed

[2] Akira S., Takeda K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4 499–511. 10.1038/nri1391 - DOI - PubMed

[3] Al Moundhri M. S., Al-Salam S., Al Mahrouqee A., Beegam S., Ali B. H. (2013). The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats. J. Med. Toxicol. 9 25–33. 10.1007/s13181-012-0239-x - DOI - PMC - PubMed

[4] Al Moundhri M. S., Al-Salam S., Al Mahrouqee A., Beegam S., Ali B. H. (2013). The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats. J. Med. Toxicol. 9 25–33. 10.1007/s13181-012-0239-x - DOI - PMC - PubMed

[5] Alessandri-Haber N., Dina O. A., Joseph E. K., Reichling D. B., Levine J. D. (2008). Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046–1057. 10.1523/JNEUROSCI.4497-07.2008 - DOI - PMC - PubMed

[6] Alessandri-Haber N., Dina O. A., Joseph E. K., Reichling D. B., Levine J. D. (2008). Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046–1057. 10.1523/JNEUROSCI.4497-07.2008 - DOI - PMC - PubMed

[7] Ameyaw E. O., Woode E., Boakye-Gyasi E., Abotsi W. K., Kyekyeku J. O., Adosraku R. K. (2014). Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 6 172–179. 10.4103/0974-8490.129041 - DOI - PMC - PubMed

[8] Ameyaw E. O., Woode E., Boakye-Gyasi E., Abotsi W. K., Kyekyeku J. O., Adosraku R. K. (2014). Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 6 172–179. 10.4103/0974-8490.129041 - DOI - PMC - PubMed

[9] Anand U., Otto W. R., Anand P. (2010). Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. Mol. Pain 6:82 10.1186/1744-8069-6-82 - DOI - PMC - PubMed

[10] Anand U., Otto W. R., Anand P. (2010). Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. Mol. Pain 6:82 10.1186/1744-8069-6-82 - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

Affiliations

Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources