Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

doi:10.3389/fphar.2015.00234

Review

. 2015 Oct 23:6:234.

doi: 10.3389/fphar.2015.00234. eCollection 2015.

Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

Xiao L Cheng¹, Hong Q Liu², Qi Wang³, Jie G Huo², Xiao N Wang², Peng Cao¹

Affiliations

¹ Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China ; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing, China.
² Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China.
³ Jiangsu Shenlong Pharmaceutical Co., Ltd. Yancheng, China.

PMID: 26557088
PMCID: PMC4615942
DOI: 10.3389/fphar.2015.00234

Review

Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

Xiao L Cheng et al. Front Pharmacol. 2015.

. 2015 Oct 23:6:234.

doi: 10.3389/fphar.2015.00234. eCollection 2015.

Authors

Xiao L Cheng¹, Hong Q Liu², Qi Wang³, Jie G Huo², Xiao N Wang², Peng Cao¹

Affiliations

¹ Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China ; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing, China.
² Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, China.
³ Jiangsu Shenlong Pharmaceutical Co., Ltd. Yancheng, China.

PMID: 26557088
PMCID: PMC4615942
DOI: 10.3389/fphar.2015.00234

Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe and dose-limiting side effect of antineoplastic drugs. It can cause sensory, motor and autonomic system dysfunction, and ultimately force patients to discontinue chemotherapy. Until now, little is understood about CIPN and no consistent caring standard is available. Since CIPN is a multifactorial disease, the clinical efficacy of single pharmacological drugs is disappointing, prompting patients to seek alternative treatment options. Complementary and alternative medicines (CAMs), especially herbal medicines, are well known for their multifaceted implications and widely used in human health care. Up to date, several phytochemicals, plant extractions, and herbal formulas have been evaluated for their potential therapeutic benefit of preventing the onset and progression of CIPN in experimental models. Clinical acupuncture has also been shown to improve CIPN symptoms. In this review, we will give an outline of our current knowledge regrading the advanced research of CIPN, the role of CAMs in alleviating CIPN and possible lacunae in research that needs to be addressed.

Keywords: Pathogenesis; acupuncture; chemotherapy-induced peripheral neurotoxicity; complementary and alternative medicine; herbal medicine.

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Figures

**FIGURE 1**
Summary of the mechanisms of chemotherapy-induced peripheral neurotoxicity (CIPN) and experimental evidence-based applications of complementary and alternative medicines (CAMs) for its prevention or treatment. All the icons in this figure were obtained from http://image.baidu.com.

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[1] Akira S., Takeda K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4 499–511. 10.1038/nri1391 - DOI - PubMed

[2] Akira S., Takeda K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4 499–511. 10.1038/nri1391 - DOI - PubMed

[3] Al Moundhri M. S., Al-Salam S., Al Mahrouqee A., Beegam S., Ali B. H. (2013). The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats. J. Med. Toxicol. 9 25–33. 10.1007/s13181-012-0239-x - DOI - PMC - PubMed

[4] Al Moundhri M. S., Al-Salam S., Al Mahrouqee A., Beegam S., Ali B. H. (2013). The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats. J. Med. Toxicol. 9 25–33. 10.1007/s13181-012-0239-x - DOI - PMC - PubMed

[5] Alessandri-Haber N., Dina O. A., Joseph E. K., Reichling D. B., Levine J. D. (2008). Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046–1057. 10.1523/JNEUROSCI.4497-07.2008 - DOI - PMC - PubMed

[6] Alessandri-Haber N., Dina O. A., Joseph E. K., Reichling D. B., Levine J. D. (2008). Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046–1057. 10.1523/JNEUROSCI.4497-07.2008 - DOI - PMC - PubMed

[7] Ameyaw E. O., Woode E., Boakye-Gyasi E., Abotsi W. K., Kyekyeku J. O., Adosraku R. K. (2014). Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 6 172–179. 10.4103/0974-8490.129041 - DOI - PMC - PubMed

[8] Ameyaw E. O., Woode E., Boakye-Gyasi E., Abotsi W. K., Kyekyeku J. O., Adosraku R. K. (2014). Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 6 172–179. 10.4103/0974-8490.129041 - DOI - PMC - PubMed

[9] Anand U., Otto W. R., Anand P. (2010). Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. Mol. Pain 6:82 10.1186/1744-8069-6-82 - DOI - PMC - PubMed

[10] Anand U., Otto W. R., Anand P. (2010). Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. Mol. Pain 6:82 10.1186/1744-8069-6-82 - DOI - PMC - PubMed

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Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

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Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective

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