Gut Microbiota of Nonalcoholic Fatty Liver Disease

doi:10.1007/s10620-016-4045-1

Review

. 2016 May;61(5):1268-81.

doi: 10.1007/s10620-016-4045-1. Epub 2016 Feb 22.

Gut Microbiota of Nonalcoholic Fatty Liver Disease

Reham M Abdou¹, Lixin Zhu^{2

3}, Robert D Baker², Susan S Baker²

Affiliations

¹ Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA. [email protected].
² Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.
³ , 3435 Main Street, 413 Biomedical Research Building, Buffalo, NY, 14214, USA.

PMID: 26898658
DOI: 10.1007/s10620-016-4045-1

Review

Gut Microbiota of Nonalcoholic Fatty Liver Disease

Reham M Abdou et al. Dig Dis Sci. 2016 May.

. 2016 May;61(5):1268-81.

doi: 10.1007/s10620-016-4045-1. Epub 2016 Feb 22.

Authors

Reham M Abdou¹, Lixin Zhu^{2

3}, Robert D Baker², Susan S Baker²

Affiliations

¹ Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA. [email protected].
² Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.
³ , 3435 Main Street, 413 Biomedical Research Building, Buffalo, NY, 14214, USA.

PMID: 26898658
DOI: 10.1007/s10620-016-4045-1

Abstract

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.

Keywords: Fibrosis; Inflammation; Microbiota and intestinal permeability; NAFLD; NASH; Steatosis.

PubMed Disclaimer

Cited by

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis.
Raselli T, Hearn T, Wyss A, Atrott K, Peter A, Frey-Wagner I, Spalinger MR, Maggio EM, Sailer AW, Schmitt J, Schreiner P, Moncsek A, Mertens J, Scharl M, Griffiths WJ, Bueter M, Geier A, Rogler G, Wang Y, Misselwitz B. Raselli T, et al. J Lipid Res. 2019 Jul;60(7):1270-1283. doi: 10.1194/jlr.M093229. Epub 2019 May 21. J Lipid Res. 2019. PMID: 31113816 Free PMC article.
Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization: Present and Future Perspectives.
Gargiullo L, Del Chierico F, D'Argenio P, Putignani L. Gargiullo L, et al. Front Microbiol. 2019 Jul 25;10:1704. doi: 10.3389/fmicb.2019.01704. eCollection 2019. Front Microbiol. 2019. PMID: 31402904 Free PMC article. Review.
Circulating microbiota-derived metabolites: a "liquid biopsy?
Aragonès G, Colom-Pellicer M, Aguilar C, Guiu-Jurado E, Martínez S, Sabench F, Antonio Porras J, Riesco D, Del Castillo D, Richart C, Auguet T. Aragonès G, et al. Int J Obes (Lond). 2020 Apr;44(4):875-885. doi: 10.1038/s41366-019-0430-0. Epub 2019 Aug 6. Int J Obes (Lond). 2020. PMID: 31388096 Free PMC article.
Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis.
Zhang Y, Li JX, Zhang Y, Wang YL. Zhang Y, et al. World J Clin Cases. 2021 Aug 16;9(23):6654-6662. doi: 10.12998/wjcc.v9.i23.6654. World J Clin Cases. 2021. PMID: 34447812 Free PMC article. Review.
The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study.
Li R, Yao Y, Gao P, Bu S. Li R, et al. Front Microbiol. 2021 Jan 14;11:555293. doi: 10.3389/fmicb.2020.555293. eCollection 2020. Front Microbiol. 2021. PMID: 33584555 Free PMC article.

See all "Cited by" articles

References

1. Am J Clin Nutr. 2014 Mar;99(3):535-42 - PubMed
1. J Gastroenterol Hepatol. 2014 Jun;29(6):1292-8 - PubMed
1. Immunol Lett. 2003 Jan 22;85(2):85-95 - PubMed
1. Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):554-60 - PubMed
1. J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):90-6 - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Grants and funding

U01 DK061728/DK/NIDDK NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Springer
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Am J Clin Nutr. 2014 Mar;99(3):535-42 - PubMed

[2] Am J Clin Nutr. 2014 Mar;99(3):535-42 - PubMed

[3] J Gastroenterol Hepatol. 2014 Jun;29(6):1292-8 - PubMed

[4] J Gastroenterol Hepatol. 2014 Jun;29(6):1292-8 - PubMed

[5] Immunol Lett. 2003 Jan 22;85(2):85-95 - PubMed

[6] Immunol Lett. 2003 Jan 22;85(2):85-95 - PubMed

[7] Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):554-60 - PubMed

[8] Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):554-60 - PubMed

[9] J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):90-6 - PubMed

[10] J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):90-6 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Gut Microbiota of Nonalcoholic Fatty Liver Disease

Affiliations

Gut Microbiota of Nonalcoholic Fatty Liver Disease

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical