Chemotherapy-induced peripheral neuropathy: an update on the current understanding
- PMID: 27408692
- PMCID: PMC4920214
- DOI: 10.12688/f1000research.8053.1
Chemotherapy-induced peripheral neuropathy: an update on the current understanding
Abstract
Chemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely fashion. The precise pathophysiology that underlies chemotherapy-induced peripheral neuropathy, in both the acute and the chronic phase, remains complex and appears to be medication specific. Recent work has begun to demonstrate and further clarify potential pathophysiological processes that predispose and, ultimately, lead to the development of chemotherapy-induced peripheral neuropathy. There is increasing evidence that the pathway to neuropathy varies with each agent. With a clearer understanding of how these agents affect the peripheral nervous system, more targeted treatments can be developed in order to optimize treatment and prevent long-term side effects.
Keywords: CIPN; Chemotherapy-induced peripheral neuropathy; Platinum agents; Taxanes; Vinca alkaloids; peripheral neuropathy.
Conflict of interest statement
No competing interests were disclosed.
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References
-
- Smith EM, Cohen JA, Pett MA, et al. : The reliability and validity of a modified total neuropathy score-reduced and neuropathic pain severity items when used to measure chemotherapy-induced peripheral neuropathy in patients receiving taxanes and platinums. Cancer Nurs. 2010;33(3):173–83. 10.1097/NCC.0b013e3181c989a3 - DOI - PubMed
-
- Shimozuma K, Ohashi Y, Takeuchi A, et al. : Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial. Support Care Cancer. 2012;20(12):3355–64. 10.1007/s00520-012-1492-x - DOI - PubMed
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