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. 2016 Sep;159(2):327-33.
doi: 10.1007/s10549-016-3939-0. Epub 2016 Aug 10.

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

Ting Bao  1 , Coby Basal  2 , Christina Seluzicki  2 , Susan Q Li  2 , Andrew D Seidman  3 , Jun J Mao  2
Affiliations

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

Ting Bao et al. Breast Cancer Res Treat. 2016 Sep.

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity associated with chemotherapy, but researchers rarely study its risk factors, fall risk, and prevalence in long-term breast cancer survivors. We aimed to determine CIPN prevalence, risk factors, and association with psychological distress and falls among long-term breast cancer survivors. We conducted Cross-sectional analyses among postmenopausal women with a history of stage I-III breast cancer who received taxane-based chemotherapy. Participants reported neuropathic symptoms of tingling/numbness in hands and/or feet on a 0-10 numerical rating scale. We conducted multivariate logistic regression analyses to evaluate risk factors associated with the presence of CIPN and the relationship between CIPN and anxiety, depression, insomnia, and patient-reported falls. Among 296 participants, 173 (58.4 %) reported CIPN symptoms, 91 (30.7 %) rated their symptoms as mild, and 82 (27.7 %) rated them moderate to severe. Compared with women of normal weight, being obese was associated with increased risk of CIPN (adjusted OR 1.94, 95 % CI: 1.03-3.65). Patients with CIPN reported greater insomnia severity, anxiety, and depression than those without (all p < 0.05). Severity of CIPN was associated with higher rates of falls, with 23.8, 31.9, and 41.5 % in the "no CIPN," "mild," and "moderate-to-severe" groups, respectively, experiencing falls (p = 0.028). The majority of long-term breast cancer survivors who received taxane-based chemotherapy reported CIPN symptoms; obesity was a significant risk factor. Those with CIPN also reported increased psychological distress and falls. Interventions need to target CIPN and comorbid psychological symptoms, and incorporate fall prevention strategies for aging breast cancer survivors.

Keywords: Breast cancer; Chemotherapy; Falls; Obesity; Peripheral neuropathy.

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Conflict of interest statement

Conflict of Interest Disclosures: The authors declare that they have no conflict of interest.

Figures

Figures 1
Figures 1
A–C. CIPN Severity and Psychological Co-morbidities (A) CIPN Severity and Rate of Anxiety (B) CIPN Severity and Rate of Depression
Figure 2
Figure 2
CIPN Severity and Kate of Falls
See this image and copyright information in PMC

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