Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

doi:10.1016/j.jad.2016.09.051

. 2017 Jan 1:207:300-304.

doi: 10.1016/j.jad.2016.09.051. Epub 2016 Oct 1.

Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

Ping Lin¹, Bingyu Ding², Chunyan Feng³, Shuwei Yin⁴, Ting Zhang⁴, Xin Qi⁴, Huiying Lv⁴, Xiaokui Guo⁵, Ke Dong⁵, Yongzhang Zhu⁵, Qingtian Li⁶

Affiliations

¹ Department of Medical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
² Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
³ Department of internal medicine, Zhejiang Medical College, Hangzhou 310053, China.
⁴ Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁵ Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁶ Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: [email protected].

PMID: 27741466
DOI: 10.1016/j.jad.2016.09.051

Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

Ping Lin et al. J Affect Disord. 2017.

. 2017 Jan 1:207:300-304.

doi: 10.1016/j.jad.2016.09.051. Epub 2016 Oct 1.

Authors

Ping Lin¹, Bingyu Ding², Chunyan Feng³, Shuwei Yin⁴, Ting Zhang⁴, Xin Qi⁴, Huiying Lv⁴, Xiaokui Guo⁵, Ke Dong⁵, Yongzhang Zhu⁵, Qingtian Li⁶

Affiliations

¹ Department of Medical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
² Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
³ Department of internal medicine, Zhejiang Medical College, Hangzhou 310053, China.
⁴ Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁵ Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁶ Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: [email protected].

PMID: 27741466
DOI: 10.1016/j.jad.2016.09.051

Abstract

Background: The diagnosis of major depression disorder (MDD) and other mental disorders were depended on some subjective survey scales. There are confirmed relationship between the gut flora and the mental states of MDD patients.

Methods: The V3-V4 region of the 16S rRNA gene was extracted from the fecal microbial communities in MDD patients, PCR amplified and sequenced on the Illumina Miseq platform.

Results: More phylum Firmicutes, less Bacteroidetes, and more genus Prevotella, Klebsiella, Streptococcus and Clostridium XI were found in MDD patients. The changes of the proportion of Prevotella and Klebsiella were consistent with Hamilton depression rating scale.

Limitations: The conclusion was limited by small sample sizes and potential uncontrollable influence factors on fecal microbiota.

Discussion: Prevotella and Klebsiella proportion in fecal microbial communities should be concerned in the diagnosis and therapeutic monitoring of MDD in future.

Keywords: Fecal microbial communities; Klebsiella; Major depressive disorder; Prevotella.

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Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

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Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

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