IL6-174G > C genetic polymorphism influences antidepressant treatment outcome
- PMID: 27796193
- DOI: 10.1080/08039488.2016.1242650
IL6-174G > C genetic polymorphism influences antidepressant treatment outcome
Abstract
Background: Major depressive disorder is a condition associated with dysregulated cytokine levels; among these, IL6. Furthermore, genetic variations within cytokine genes have been proposed to predict antidepressant treatment outcome.
Objectives: This study aims to evaluate the role of IL6-174G > C and IL6R D358A A > C functional polymorphisms in antidepressant treatment phenotypes, specifically remission, relapse, and treatment resistant depression (TRD).
Methods: The referred polymorphisms were genotyped in 80 MDD patients followed at Hospital Magalhães Lemos, Portugal, within a period of 27 months.
Results: It was found that patients carrying IL6-174 GC genotype present a protection towards the development of TRD (OR = 0.242; 95% CI = 0.068-0.869; p = .038), when compared with GG genotype. Additionally, carriers of IL6-174 CC genotype remit earlier than patients with IL6-174 GG/GC genotypes, with a median time to remission of 6 weeks for CC carriers and 15 weeks for GG or GC carriers (p = .030, Log-rank test). No association was found between IL6R D358A genetic polymorphism and any of the treatment phenotypes evaluated.
Conclusions: The IL6-174G > C polymorphism influences antidepressant treatment outcome in this sub-set of MDD patients, providing a putative mechanistic link for the dysregulated IL-6 levels described in the literature in patients with TRD.
Keywords: IL6; antidepressants; genetic polymorphisms; treatment resistant depression.
Similar articles
-
FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression.J Affect Disord. 2015 Oct 1;185:164-9. doi: 10.1016/j.jad.2015.06.027. Epub 2015 Jun 24. J Affect Disord. 2015. PMID: 26186532
-
The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report.Neurosci Lett. 2016 May 27;622:107-12. doi: 10.1016/j.neulet.2016.03.026. Epub 2016 Mar 18. Neurosci Lett. 2016. PMID: 27001087
-
ABCB1 C1236T, G2677TA and C3435T Genetic Polymorphisms and Antidepressant Response Phenotypes: Results from a Portuguese Major Depressive Disorder Cohort.Int J Mol Sci. 2024 May 8;25(10):5112. doi: 10.3390/ijms25105112. Int J Mol Sci. 2024. PMID: 38791151 Free PMC article.
-
Role of Interleukin-6 in Depressive Disorder.Int J Mol Sci. 2020 Mar 22;21(6):2194. doi: 10.3390/ijms21062194. Int J Mol Sci. 2020. PMID: 32235786 Free PMC article. Review.
-
The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review.Int J Mol Sci. 2020 Jan 28;21(3):826. doi: 10.3390/ijms21030826. Int J Mol Sci. 2020. PMID: 32012861 Free PMC article.
Cited by
-
Treatment-Resistant Depression in Portugal: Perspective From Psychiatry Experts.Front Psychiatry. 2022 Mar 30;13:824919. doi: 10.3389/fpsyt.2022.824919. eCollection 2022. Front Psychiatry. 2022. PMID: 35432028 Free PMC article.
-
Understanding the Relation Between Early-Life Adversity and Depression Symptoms: The Moderating Role of Sex and an Interleukin-1β Gene Variant.Front Psychiatry. 2019 Mar 22;10:151. doi: 10.3389/fpsyt.2019.00151. eCollection 2019. Front Psychiatry. 2019. PMID: 30967802 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
