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Review
. 2018 Apr 28;24(16):1734-1747.
doi: 10.3748/wjg.v24.i16.1734.

Diversion colitis and pouchitis: A mini-review

Kentaro Tominaga  1 , Kenya Kamimura  2 , Kazuya Takahashi  1 , Junji Yokoyama  1 , Satoshi Yamagiwa  1 , Shuji Terai  1
Affiliations
Review

Diversion colitis and pouchitis: A mini-review

Kentaro Tominaga et al. World J Gastroenterol. .

Abstract

Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts remain asymptomatic, it has been reported that diversion colitis and pouchitis might occur in almost all patients with diversion. Surgical closure of the stoma, with reestablishment of gut continuity, is the only curative intervention available for patients with diversion disease. Pharmacologic treatments using short-chain fatty acids, mesalamine, or corticosteroids are reportedly effective for those who are not candidates for surgical reestablishment; however, there are no established assessment criteria for determining the severity of diversion colitis, and no management strategies to date. Therefore, in this mini-review, we summarize and review various recently-reported treatments for diversion disease. We are hopeful that the information summarized here will assist physicians who treat patients with diversion colitis and pouchitis, leading to better case management.

Keywords: Diversion colitis; Diversion pouchitis; Ileitis; Inflammatory bowel disease.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no current financial arrangement or affiliation with any organization that may have a direct influence on their work.

Figures

Figure 1
Figure 1
Schematic presentation of diversion colitis and pouchitis.
See this image and copyright information in PMC

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