Breast cancer treatment and its effects on aging

doi:10.1016/j.jgo.2018.07.010

Review

. 2019 Mar;10(2):346-355.

doi: 10.1016/j.jgo.2018.07.010. Epub 2018 Aug 2.

Breast cancer treatment and its effects on aging

Leslie Chang¹, Lauren S Weiner², Sheri J Hartman², Steve Horvath³, Dilip Jeste⁴, Paul S Mischel⁵, Deborah M Kado⁶

Affiliations

¹ Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; Department of Internal Medicine, School of Medicine University of California, San Diego, United States.
² Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; University of California San Diego, Moores Cancer Center, La Jolla, CA, United States.
³ Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, United States.
⁴ Departments of Psychiatry & Neuroscience, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, United States.
⁵ Department of Pathology, School of Medicine, University of California, San Diego, United States; Ludwig Institute for Cancer Research, University of California, San Diego, United States.
⁶ Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; Department of Internal Medicine, School of Medicine University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, United States. Electronic address: [email protected].

PMID: 30078714
PMCID: PMC7062379
DOI: 10.1016/j.jgo.2018.07.010

Review

Breast cancer treatment and its effects on aging

Leslie Chang et al. J Geriatr Oncol. 2019 Mar.

. 2019 Mar;10(2):346-355.

doi: 10.1016/j.jgo.2018.07.010. Epub 2018 Aug 2.

Authors

Leslie Chang¹, Lauren S Weiner², Sheri J Hartman², Steve Horvath³, Dilip Jeste⁴, Paul S Mischel⁵, Deborah M Kado⁶

Affiliations

¹ Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; Department of Internal Medicine, School of Medicine University of California, San Diego, United States.
² Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; University of California San Diego, Moores Cancer Center, La Jolla, CA, United States.
³ Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, United States.
⁴ Departments of Psychiatry & Neuroscience, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, United States.
⁵ Department of Pathology, School of Medicine, University of California, San Diego, United States; Ludwig Institute for Cancer Research, University of California, San Diego, United States.
⁶ Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; Department of Internal Medicine, School of Medicine University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, United States. Electronic address: [email protected].

PMID: 30078714
PMCID: PMC7062379
DOI: 10.1016/j.jgo.2018.07.010

Abstract

Breast cancer is the most common cancer of women in the United States. It is also proving to be one of the most treatable. Early detection, surgical intervention, therapeutic radiation, cytotoxic chemotherapies and molecularly targeted agents are transforming the lives of patients with breast cancer, markedly improving their survival. Although current breast cancer treatments are largely successful in producing cancer remission and extending lifespan, there is concern that these treatments may have long lasting detrimental effects on cancer survivors, in part, through their impact on non-tumor cells. Presently, the impact of breast cancer treatment on normal cells, its impact on cellular function and its effect on the overall function of the individual are incompletely understood. In particular, it is unclear whether breast cancer and/or its treatments are associated with an accelerated aging phenotype. In this review, we consider breast cancer survivorship from the perspective of accelerated aging, and discuss the evidence suggesting that women treated for breast cancer may suffer from an increased rate of physical and cognitive decline that likely corresponds with underlying vulnerabilities of genome instability, epigenetic changes, and cellular senescence.

Keywords: Aging; Breast cancer; Cognitive decline; Epigenetic clock; Physiological decline; Senescence; Telomere length; Tissue age; p16(INKa).

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

The authors have no conflicts of interest to declare.

Figures

**Fig. 1.**
Cytotoxic therapy effects on tumor versus normal cells.

See this image and copyright information in PMC

Cited by

Factors associated with self-reported falls, balance or walking difficulty in older survivors of breast, colorectal, lung, or prostate cancer: Results from Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage.
Huang MH, Blackwood J, Godoshian M, Pfalzer L. Huang MH, et al. PLoS One. 2018 Dec 19;13(12):e0208573. doi: 10.1371/journal.pone.0208573. eCollection 2018. PLoS One. 2018. PMID: 30566443 Free PMC article.
Interrelationship of Seasons with Inflammation, Red Meat, Fruit, and Vegetable Intakes, Cardio-Metabolic Health, and Smoking Status among Breast Cancer Survivors.
Wu T, Shinde R, Castro R, Pierce JP. Wu T, et al. J Clin Med. 2021 Feb 7;10(4):636. doi: 10.3390/jcm10040636. J Clin Med. 2021. PMID: 33562354 Free PMC article.
Covid-19 Pandemic Impact on Breast Cancer Detection-The Major Effects Over an Early Diagnosis.
Nica RE, Camen GC, Şerbănescu MS, Florescu LM, Gheonea IA. Nica RE, et al. Curr Health Sci J. 2021 Oct-Dec;47(4):494-500. doi: 10.12865/CHSJ.47.04.03. Epub 2021 Dec 31. Curr Health Sci J. 2021. PMID: 35444824 Free PMC article.
Antidepressant Sertraline Hydrochloride Inhibits the Growth of HER2+ AU565 Breast Cancer Cell Line through Induction of Apoptosis and Cell Cycle Arrest.
Fayyaz S, Atia-Tul-Wahab, Irshad R, Siddiqui RA, Choudhary MI. Fayyaz S, et al. Anticancer Agents Med Chem. 2024;24(14):1038-1046. doi: 10.2174/0118715206304918240509111700. Anticancer Agents Med Chem. 2024. PMID: 38766835
The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment.
Alven S, Aderibigbe BA. Alven S, et al. Pharmaceutics. 2020 Dec 15;12(12):1212. doi: 10.3390/pharmaceutics12121212. Pharmaceutics. 2020. PMID: 33333778 Free PMC article. Review.

See all "Cited by" articles

References

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017;67(1): 7–30 Epub 2017/01/06 10.3322/caac.21387. - DOI - PubMed
1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013;153(6):1194–217. 10.1016/j.cell.2013.05.039. - DOI - PMC - PubMed
1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144 (5):646–74. 10.1016/j.cell.2011.02.013. - DOI - PubMed
1. Reimer T, Gerber B. Quality-of-life considerations in the treatment of early-stage breast cancer in the elderly. Drugs Aging 2010;27(10):791–800. 10.2165/11584700-000000000-00000. - DOI - PubMed
1. Cohen HJ, Lan L, Archer L, Kornblith AB. Impact of age, comorbidity and symptoms on physical function in long-term breast cancer survivors (CALGB 70803). J Geriatr Oncol 2012;3(2). 10.1016/j.jgo.2012.01.005 (82–9). - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017;67(1): 7–30 Epub 2017/01/06 10.3322/caac.21387. - DOI - PubMed

[2] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017;67(1): 7–30 Epub 2017/01/06 10.3322/caac.21387. - DOI - PubMed

[3] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013;153(6):1194–217. 10.1016/j.cell.2013.05.039. - DOI - PMC - PubMed

[4] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013;153(6):1194–217. 10.1016/j.cell.2013.05.039. - DOI - PMC - PubMed

[5] Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144 (5):646–74. 10.1016/j.cell.2011.02.013. - DOI - PubMed

[6] Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144 (5):646–74. 10.1016/j.cell.2011.02.013. - DOI - PubMed

[7] Reimer T, Gerber B. Quality-of-life considerations in the treatment of early-stage breast cancer in the elderly. Drugs Aging 2010;27(10):791–800. 10.2165/11584700-000000000-00000. - DOI - PubMed

[8] Reimer T, Gerber B. Quality-of-life considerations in the treatment of early-stage breast cancer in the elderly. Drugs Aging 2010;27(10):791–800. 10.2165/11584700-000000000-00000. - DOI - PubMed

[9] Cohen HJ, Lan L, Archer L, Kornblith AB. Impact of age, comorbidity and symptoms on physical function in long-term breast cancer survivors (CALGB 70803). J Geriatr Oncol 2012;3(2). 10.1016/j.jgo.2012.01.005 (82–9). - DOI - PMC - PubMed

[10] Cohen HJ, Lan L, Archer L, Kornblith AB. Impact of age, comorbidity and symptoms on physical function in long-term breast cancer survivors (CALGB 70803). J Geriatr Oncol 2012;3(2). 10.1016/j.jgo.2012.01.005 (82–9). - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Breast cancer treatment and its effects on aging

Affiliations

Breast cancer treatment and its effects on aging

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical