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Review
. 2001 Sep 13;413(6852):203-10.
doi: 10.1038/35093019.

Molecular mechanisms of nociception

D Julius  1 , A I Basbaum
Affiliations
Review

Molecular mechanisms of nociception

D Julius et al. Nature. .

Abstract

The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated - at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.

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