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Review
. 2019 Jun;35(3):253-260.
doi: 10.1016/j.soncn.2019.04.006. Epub 2019 Apr 30.

Mechanisms, Predictors, and Challenges in Assessing and Managing Painful Chemotherapy-Induced Peripheral Neuropathy

Grace A Kanzawa-Lee  1 , Robert Knoerl  2 , Clare Donohoe  3 , Celia M Bridges  3 , Ellen M Lavoie Smith  3
Affiliations
Review

Mechanisms, Predictors, and Challenges in Assessing and Managing Painful Chemotherapy-Induced Peripheral Neuropathy

Grace A Kanzawa-Lee et al. Semin Oncol Nurs. 2019 Jun.

Abstract

Objective: To describe the known predictors and pathophysiological mechanisms of chronic painful chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors and the challenges in assessing and managing it.

Data sources: PubMed/Medline, CINAHL, Scopus, and PsycINFO.

Conclusion: The research on chronic painful CIPN is limited. Additional research is needed to identify the predictors and pathophysiological mechanisms of chronic painful CIPN to inform the development of assessment tools and management options for this painful and possibly debilitating condition.

Implications for nursing practice: Recognition of the predictors of chronic painful CIPN and proactive CIPN assessment and palliative management are important steps in reducing its impact on physical function and quality of life.

Keywords: Cancer; Centralized pain; Chemotherapy-induced peripheral neuropathy; Chronic pain; Neuropathic pain; Polyneuropathy.

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Conflict of interest statement

Conflicts of interest: Robert Knoerl reports a consulting honorarium from System Analytic. The other authors have no conflicts of interest to disclose.

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