Tobacco smoking and death from prostate cancer in US veterans

doi:10.1038/s41391-019-0178-6

. 2020 Jun;23(2):252-259.

doi: 10.1038/s41391-019-0178-6. Epub 2019 Oct 17.

Tobacco smoking and death from prostate cancer in US veterans

Paul Riviere^{1

2}, Abhishek Kumar^{1

2}, Elaine Luterstein¹, Lucas K Vitzthum^{1

2}, Vinit Nalawade^{1

2}, Reith R Sarkar^{1

2}, Alex K Bryant^{1

2}, John P Einck¹, Arno J Mundt¹, James D Murphy^{1

2}, Brent S Rose^{3

4}

Affiliations

¹ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
² VA San Diego Health Care System, La Jolla, CA, USA.
³ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. [email protected].
⁴ VA San Diego Health Care System, La Jolla, CA, USA. [email protected].

PMID: 31624316
DOI: 10.1038/s41391-019-0178-6

Tobacco smoking and death from prostate cancer in US veterans

Paul Riviere et al. Prostate Cancer Prostatic Dis. 2020 Jun.

. 2020 Jun;23(2):252-259.

doi: 10.1038/s41391-019-0178-6. Epub 2019 Oct 17.

Authors

Affiliations

¹ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
² VA San Diego Health Care System, La Jolla, CA, USA.
³ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. [email protected].
⁴ VA San Diego Health Care System, La Jolla, CA, USA. [email protected].

PMID: 31624316
DOI: 10.1038/s41391-019-0178-6

Abstract

Background: Cigarette smoking is a risk factor for mortality in several genitourinary cancers, likely due to accumulation of carcinogens in urine. However, in prostate cancer (PC) the link has been less studied. We evaluated differences in prostate cancer-specific mortality (PCSM) between current smokers, past smokers, and never smokers diagnosed with PC.

Methods: This was a retrospective cohort study of PCSM in men diagnosed with PC between 2000 and 2015 treated in the US Veterans Affairs health care system, using competing risk regression analyses.

Results: The cohort included 73,668 men (current smokers: 22,608 (30.7%), past smokers: 23,695 (32.1%), and never smokers: 27,365 (37.1%)). Median follow-up was 5.9 years. Current smoker patients were younger at presentation (median age current: 63, never: 66; p < 0.001), and had more advanced disease stage (stage IV disease current: 5.3%, never: 4.3%; p < 0.04). The 10-year incidence of PCSM was 5.2%, 4.8%, and 4.5% for current, past, and never smokers, respectively. On competing risk regression, current smoking was associated with increased PCSM (subdistribution hazard ratio: 1.14, 95% confidence interval: (1.05-1.24), p = 0.002), whereas past smoking was not. Hierarchical regression suggests that this increased risk was partially attributable to tumor characteristics.

Conclusions: Smoking at the time of diagnosis is associated with a higher risk of dying from PC as well as other causes of death. In contrast, past smoking was not associated with PCSM suggesting that smoking may be a modifiable risk factor. PC diagnosis may be an important opportunity to discuss smoking cessation.

PubMed Disclaimer

Cited by

Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer.
Marino P, Mininni M, Deiana G, Marino G, Divella R, Bochicchio I, Giuliano A, Lapadula S, Lettini AR, Sanseverino F. Marino P, et al. Nutrients. 2024 Mar 11;16(6):800. doi: 10.3390/nu16060800. Nutrients. 2024. PMID: 38542712 Free PMC article. Review.
A decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries: a systematic review and meta-analysis.
Zhong P, Lin Y, Chen T. Zhong P, et al. Chin Neurosurg J. 2021 Nov 1;7(1):45. doi: 10.1186/s41016-021-00261-1. Chin Neurosurg J. 2021. PMID: 34724983 Free PMC article.
Prostate Cancer: Emerging Modifiable Risk Factors and Therapeutic Strategies in the Management of Advanced Cancer.
Bossio S, Urlandini L, Perri A, Conforti F, Aversa A, Di Agostino S, Rago V. Bossio S, et al. Life (Basel). 2024 Aug 30;14(9):1094. doi: 10.3390/life14091094. Life (Basel). 2024. PMID: 39337878 Free PMC article. Review.
Inflammation and Prostate Cancer: A Multidisciplinary Approach to Identifying Opportunities for Treatment and Prevention.
Huang L, LaBonte MJ, Craig SG, Finn SP, Allott EH. Huang L, et al. Cancers (Basel). 2022 Mar 8;14(6):1367. doi: 10.3390/cancers14061367. Cancers (Basel). 2022. PMID: 35326519 Free PMC article. Review.
Post-diagnostic health behaviour scores in relation to fatal prostate cancer.
Graff RE, Langlais CS, Van Blarigan EL, Pernar CH, Stampfer MJ, Giovannucci EL, Mucci LA, Chan JM, Kenfield SA. Graff RE, et al. Br J Cancer. 2022 Nov;127(9):1670-1679. doi: 10.1038/s41416-022-01948-7. Epub 2022 Aug 26. Br J Cancer. 2022. PMID: 36028533 Free PMC article.

See all "Cited by" articles

References

1. Services, U. S. D. How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general. Rep No. 2010;9780160840784:792.
1. Cumberbatch MG, Rota M, Catto JWF, La Vecchia C. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. Eur Urol. 2016;70:458–66. https://doi.org/10.1016/j.eururo.2015.06.042 - DOI - PubMed
1. Zeegers MPA, Tan FES, Dorant E, Van Den Brandt PA. The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer. 2000;89:630–9. 10.1002/1097-0142(20000801)89:3<630:AID-CNCR19>3.0.CO;2-Q - DOI
1. Steinberger E, Kollmeier M, McBride S, Novak C, Pei X, Zelefsky M. Cigarette smoking during external beam radiation therapy for prostate cancer is associated with an increased risk of prostate cancer-specific mortality and treatment-related toxicity. BJU Int. 2015;116:596–603. https://doi.org/10.1111/bju.12969 - DOI - PubMed
1. Kenfield SA, Stampfer MJ, Chan JM, Giovannucci E. Smoking and prostate cancer survival and recurrence. JAMA. 2011;305:2548. https://doi.org/10.1001/jama.2011.879 - DOI - PubMed - PMC

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

TL1TR001443/NH/NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Services, U. S. D. How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general. Rep No. 2010;9780160840784:792.

[2] Services, U. S. D. How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general. Rep No. 2010;9780160840784:792.

[3] Cumberbatch MG, Rota M, Catto JWF, La Vecchia C. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. Eur Urol. 2016;70:458–66. https://doi.org/10.1016/j.eururo.2015.06.042 - DOI - PubMed

[4] Cumberbatch MG, Rota M, Catto JWF, La Vecchia C. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. Eur Urol. 2016;70:458–66. https://doi.org/10.1016/j.eururo.2015.06.042 - DOI - PubMed

[5] Zeegers MPA, Tan FES, Dorant E, Van Den Brandt PA. The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer. 2000;89:630–9. 10.1002/1097-0142(20000801)89:3<630:AID-CNCR19>3.0.CO;2-Q - DOI

[6] Zeegers MPA, Tan FES, Dorant E, Van Den Brandt PA. The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer. 2000;89:630–9. 10.1002/1097-0142(20000801)89:3<630:AID-CNCR19>3.0.CO;2-Q - DOI

[7] Steinberger E, Kollmeier M, McBride S, Novak C, Pei X, Zelefsky M. Cigarette smoking during external beam radiation therapy for prostate cancer is associated with an increased risk of prostate cancer-specific mortality and treatment-related toxicity. BJU Int. 2015;116:596–603. https://doi.org/10.1111/bju.12969 - DOI - PubMed

[8] Steinberger E, Kollmeier M, McBride S, Novak C, Pei X, Zelefsky M. Cigarette smoking during external beam radiation therapy for prostate cancer is associated with an increased risk of prostate cancer-specific mortality and treatment-related toxicity. BJU Int. 2015;116:596–603. https://doi.org/10.1111/bju.12969 - DOI - PubMed

[9] Kenfield SA, Stampfer MJ, Chan JM, Giovannucci E. Smoking and prostate cancer survival and recurrence. JAMA. 2011;305:2548. https://doi.org/10.1001/jama.2011.879 - DOI - PubMed - PMC

[10] Kenfield SA, Stampfer MJ, Chan JM, Giovannucci E. Smoking and prostate cancer survival and recurrence. JAMA. 2011;305:2548. https://doi.org/10.1001/jama.2011.879 - DOI - PubMed - PMC

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Tobacco smoking and death from prostate cancer in US veterans

Affiliations

Tobacco smoking and death from prostate cancer in US veterans

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous