doi: 10.1016/0006-8993(88)90541-0.
Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid
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- PMID: 3196905
- DOI: 10.1016/0006-8993(88)90541-0
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Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid
Brain Res.
.
Abstract
Electroencephalographic and clinical observations of the rats were done for 3 months after microinjection of kainic acid (KA, 0.2-1.2 micrograms) into the unilateral amygdala. With high doses of KA (0.6-1.2 micrograms) injection, 64% of rats developed spontaneous limbic seizures 14-25 days after KA injection. Among those which developed spontaneous limbic seizures, 33% of rats developed secondarily generalized seizures 26-71 days after KA injection. This is one of the best chronic models of spontaneous complex partial seizure secondarily generalized in rats, which is economical and easy to prepare.
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