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. 2020 Apr 24;368(6489):395-400.
doi: 10.1126/science.aba9757. Epub 2020 Mar 6.

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

Matteo Chinazzi  1 , Jessica T Davis  1 , Marco Ajelli  2 , Corrado Gioannini  3 , Maria Litvinova  3 , Stefano Merler  2 , Ana Pastore Y Piontti  1 , Kunpeng Mu  1 , Luca Rossi  3 , Kaiyuan Sun  4 , Cécile Viboud  4 , Xinyue Xiong  1 , Hongjie Yu  5 , M Elizabeth Halloran  6   7 , Ira M Longini Jr  8 , Alessandro Vespignani  9   3
Affiliations

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

Matteo Chinazzi et al. Science. .

Abstract

Motivated by the rapid spread of coronavirus disease 2019 (COVID-19) in mainland China, we use a global metapopulation disease transmission model to project the impact of travel limitations on the national and international spread of the epidemic. The model is calibrated on the basis of internationally reported cases and shows that, at the start of the travel ban from Wuhan on 23 January 2020, most Chinese cities had already received many infected travelers. The travel quarantine of Wuhan delayed the overall epidemic progression by only 3 to 5 days in mainland China but had a more marked effect on the international scale, where case importations were reduced by nearly 80% until mid-February. Modeling results also indicate that sustained 90% travel restrictions to and from mainland China only modestly affect the epidemic trajectory unless combined with a 50% or higher reduction of transmission in the community.

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Figures

Fig. 1
Fig. 1. Effect of the Wuhan travel ban on the COVID-19 epidemic.
(A) Trajectory of the COVID-19 epidemic in Chinese locations (excluding Wuhan) under the ban on travel to and from Wuhan as of 23 January 2020. Trajectories are also plotted for scenarios with relative transmissibility reduction r and international travel restrictions. Lines represent median cumulative number of infections; shaded areas represent 90% reference ranges. (B) Correlation between the number of cases reported in each province by the WHO situation report and model projections on 1 February 2020 (no provinces were reporting zero cases by this date). Circle size is proportional to the population size in each province. (C) Projections of the average detected number of daily international case importations for different modeling scenarios. Shaded areas represent 99% reference ranges. We report the observed data of international case importations with a travel history from China, classified by arrival date. We also report scenarios with relative transmissibility reduction r. Data points after 23 January 2020 were used for out-of-sample validation and were not used in the model calibration.
Fig. 2
Fig. 2. Effects of Wuhan travel ban on COVID-19 incidence across mainland China.
(A) Relative incidence reduction as of 1 February 2020. Circle color represents the relative reduction in the number of infections, whereas circle size corresponds to population. (B) Projected cumulative number of infections by the same date, after implementation of travel restrictions in Wuhan. A resolution of 0.25° by 0.25° geographical cells was used in the model.
Fig. 3
Fig. 3. Relative risk of case importation.
Contribution to the relative risk of importation from the 10 Chinese cities with the highest rates of disease (plus the rest of mainland China) until 22 January 2020 (left) and after the Wuhan travel ban from 23 January to 1 March 2020 (right). The listed countries are the 20 countries at greatest risk of case importation. Flows are proportional to the relative probability that a single imported case will travel from a given origin to a specific destination.
Fig. 4
Fig. 4. Combined effects of travel and transmissibility reductions on the epidemic.
(A) Median total number of imported infections from mainland China with no transmissibility reduction and travel reductions of 40 and 90%. (B) Same as (A) for the moderate transmissibility reduction scenario (r = 0.75). (C) Same as (A) for the strong transmissibility reduction scenario (r = 0.5). Shaded areas represent 90% CIs. (D) Disease incidence in mainland China, excluding Wuhan, for the scenarios plotted in (A) to (C).
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