The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

doi:10.1186/s13054-020-02995-3

Meta-Analysis

. 2020 May 26;24(1):255.

doi: 10.1186/s13054-020-02995-3.

The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Muhammad Aziz¹, Rawish Fatima², Wade Lee-Smith³, Ragheb Assaly⁴

Affiliations

¹ Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA. [email protected].
² Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA.
³ University of Toledo Libraries, University of Toledo Medical Center, Toledo, OH, USA.
⁴ Division of Pulmonary and Critical Care Medicine, University of Toledo Medical Center, Toledo, OH, USA.

PMID: 32456658
PMCID: PMC7249975
DOI: 10.1186/s13054-020-02995-3

Meta-Analysis

The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Muhammad Aziz et al. Crit Care. 2020.

. 2020 May 26;24(1):255.

doi: 10.1186/s13054-020-02995-3.

Authors

Muhammad Aziz¹, Rawish Fatima², Wade Lee-Smith³, Ragheb Assaly⁴

Affiliations

¹ Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA. [email protected].
² Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA.
³ University of Toledo Libraries, University of Toledo Medical Center, Toledo, OH, USA.
⁴ Division of Pulmonary and Critical Care Medicine, University of Toledo Medical Center, Toledo, OH, USA.

PMID: 32456658
PMCID: PMC7249975
DOI: 10.1186/s13054-020-02995-3

No abstract available

Keywords: COVID-19; Hypoalbuminemia; SARS-CoV-2; Severe disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing/conflict of interest.

Figures

**Fig. 1**
Forest plot demonstrating a meta-analysis comparing mean serum albumin, b leave-one-out meta-analysis comparing mean serum albumin, and c meta-analysis comparing hypoalbuminemia status for patients in severe vs non-severe group (C.I. confidence interval)

See this image and copyright information in PMC

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References

1. Aziz M, Fatima R, Assaly R. Elevated interleukin-6 and severe COVID-19: a meta-analysis. J Med Virol. 2020. 10.1002/jmv.25948. - PMC - PubMed
1. Huang Chaolin, Wang Yeming, Li Xingwang, Ren Lili, Zhao Jianping, Hu Yi, Zhang Li, Fan Guohui, Xu Jiuyang, Gu Xiaoying, Cheng Zhenshun, Yu Ting, Xia Jiaan, Wei Yuan, Wu Wenjuan, Xie Xuelei, Yin Wen, Li Hui, Liu Min, Xiao Yan, Gao Hong, Guo Li, Xie Jungang, Wang Guangfa, Jiang Rongmeng, Gao Zhancheng, Jin Qi, Wang Jianwei, Cao Bin. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
1. Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. 10.1136/bmj.m1091. - PMC - PubMed
1. Liu Yingxia, Yang Yang, Zhang Cong, Huang Fengming, Wang Fuxiang, Yuan Jing, Wang Zhaoqin, Li Jinxiu, Li Jianming, Feng Cheng, Zhang Zheng, Wang Lifei, Peng Ling, Chen Li, Qin Yuhao, Zhao Dandan, Tan Shuguang, Yin Lu, Xu Jun, Zhou Congzhao, Jiang Chengyu, Liu Lei. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences. 2020;63(3):364–374. doi: 10.1007/s11427-020-1643-8. - DOI - PMC - PubMed
1. Chen Guang, Wu Di, Guo Wei, Cao Yong, Huang Da, Wang Hongwu, Wang Tao, Zhang Xiaoyun, Chen Huilong, Yu Haijing, Zhang Xiaoping, Zhang Minxia, Wu Shiji, Song Jianxin, Chen Tao, Han Meifang, Li Shusheng, Luo Xiaoping, Zhao Jianping, Ning Qin. Clinical and immunological features of severe and moderate coronavirus disease 2019. Journal of Clinical Investigation. 2020;130(5):2620–2629. doi: 10.1172/JCI137244. - DOI - PMC - PubMed

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[1] Aziz M, Fatima R, Assaly R. Elevated interleukin-6 and severe COVID-19: a meta-analysis. J Med Virol. 2020. 10.1002/jmv.25948. - PMC - PubMed

[2] Aziz M, Fatima R, Assaly R. Elevated interleukin-6 and severe COVID-19: a meta-analysis. J Med Virol. 2020. 10.1002/jmv.25948. - PMC - PubMed

[3] Huang Chaolin, Wang Yeming, Li Xingwang, Ren Lili, Zhao Jianping, Hu Yi, Zhang Li, Fan Guohui, Xu Jiuyang, Gu Xiaoying, Cheng Zhenshun, Yu Ting, Xia Jiaan, Wei Yuan, Wu Wenjuan, Xie Xuelei, Yin Wen, Li Hui, Liu Min, Xiao Yan, Gao Hong, Guo Li, Xie Jungang, Wang Guangfa, Jiang Rongmeng, Gao Zhancheng, Jin Qi, Wang Jianwei, Cao Bin. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed

[4] Huang Chaolin, Wang Yeming, Li Xingwang, Ren Lili, Zhao Jianping, Hu Yi, Zhang Li, Fan Guohui, Xu Jiuyang, Gu Xiaoying, Cheng Zhenshun, Yu Ting, Xia Jiaan, Wei Yuan, Wu Wenjuan, Xie Xuelei, Yin Wen, Li Hui, Liu Min, Xiao Yan, Gao Hong, Guo Li, Xie Jungang, Wang Guangfa, Jiang Rongmeng, Gao Zhancheng, Jin Qi, Wang Jianwei, Cao Bin. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed

[5] Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. 10.1136/bmj.m1091. - PMC - PubMed

[6] Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. 10.1136/bmj.m1091. - PMC - PubMed

[7] Liu Yingxia, Yang Yang, Zhang Cong, Huang Fengming, Wang Fuxiang, Yuan Jing, Wang Zhaoqin, Li Jinxiu, Li Jianming, Feng Cheng, Zhang Zheng, Wang Lifei, Peng Ling, Chen Li, Qin Yuhao, Zhao Dandan, Tan Shuguang, Yin Lu, Xu Jun, Zhou Congzhao, Jiang Chengyu, Liu Lei. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences. 2020;63(3):364–374. doi: 10.1007/s11427-020-1643-8. - DOI - PMC - PubMed

[8] Liu Yingxia, Yang Yang, Zhang Cong, Huang Fengming, Wang Fuxiang, Yuan Jing, Wang Zhaoqin, Li Jinxiu, Li Jianming, Feng Cheng, Zhang Zheng, Wang Lifei, Peng Ling, Chen Li, Qin Yuhao, Zhao Dandan, Tan Shuguang, Yin Lu, Xu Jun, Zhou Congzhao, Jiang Chengyu, Liu Lei. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences. 2020;63(3):364–374. doi: 10.1007/s11427-020-1643-8. - DOI - PMC - PubMed

[9] Chen Guang, Wu Di, Guo Wei, Cao Yong, Huang Da, Wang Hongwu, Wang Tao, Zhang Xiaoyun, Chen Huilong, Yu Haijing, Zhang Xiaoping, Zhang Minxia, Wu Shiji, Song Jianxin, Chen Tao, Han Meifang, Li Shusheng, Luo Xiaoping, Zhao Jianping, Ning Qin. Clinical and immunological features of severe and moderate coronavirus disease 2019. Journal of Clinical Investigation. 2020;130(5):2620–2629. doi: 10.1172/JCI137244. - DOI - PMC - PubMed

[10] Chen Guang, Wu Di, Guo Wei, Cao Yong, Huang Da, Wang Hongwu, Wang Tao, Zhang Xiaoyun, Chen Huilong, Yu Haijing, Zhang Xiaoping, Zhang Minxia, Wu Shiji, Song Jianxin, Chen Tao, Han Meifang, Li Shusheng, Luo Xiaoping, Zhao Jianping, Ning Qin. Clinical and immunological features of severe and moderate coronavirus disease 2019. Journal of Clinical Investigation. 2020;130(5):2620–2629. doi: 10.1172/JCI137244. - DOI - PMC - PubMed

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The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Affiliations

The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Authors

Affiliations

Conflict of interest statement

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