Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar 16;11(6):1010.
doi: 10.3390/cells11061010.

Cardiovascular Inflammaging: Mechanisms and Translational Aspects

Maria Luisa Barcena  1   2 , Muhammad Aslam  3   4   5 , Sofya Pozdniakova  1   6 , Kristina Norman  1   7   8 , Yury Ladilov  1   9
Affiliations
Review

Cardiovascular Inflammaging: Mechanisms and Translational Aspects

Maria Luisa Barcena et al. Cells. .

Abstract

Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.

Keywords: cardiac inflammaging; microbiome; mitochondrial homeostasis; vascular senescence.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of some signaling pathways involved in cardiac inflammaging development and potential treatment strategies. Systemic aging leads to low-grade systemic inflammation, which among numerous other mechanisms includes type 2 diabetes and gut microbiome dysbiosis. Cardiac aging is linked with (i) increased expression of pro-inflammatory factors and immune cell infiltration, (ii) downregulation of main energy regulating mechanisms, such as pAMPK and sirtuin, and (iii) mitochondrial dysfunction. Together with the low-grade systemic inflammation, it leads to cardiac inflammation and endothelial/myocardial dysfunction. The potential treatment strategies are shown.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Toba H., de Castro Bras L.E., Baicu C.F., Zile M.R., Lindsey M.L., Bradshaw A.D. Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. Am. J. Physiol. Cell Physiol. 2015;308:C972–C982. doi: 10.1152/ajpcell.00402.2014. - DOI - PMC - PubMed
    1. Kinn P.M., Holdren G.O., Westermeyer B.A., Abuissa M., Fischer C.L., Fairley J.A., Brogden K.A., Brogden N.K. Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin. Sci. Rep. 2015;5:10472. doi: 10.1038/srep10472. - DOI - PMC - PubMed
    1. Fabbri E., An Y., Zoli M., Simonsick E.M., Guralnik J.M., Bandinelli S., Boyd C.M. Aging and the burden of multimorbidity: Associations with inflammatory and anabolic hormonal biomarkers. J. Gerontol. A Biol. Sci. Med. Sci. 2015;70:63–70. doi: 10.1093/gerona/glu127. - DOI - PMC - PubMed
    1. Ballou S.P., Lozanski F.B., Hodder S., Rzewnicki D.L., Mion L.C., Sipe J.D., Ford A.B., Kushner I. Quantitative and qualitative alterations of acute-phase proteins in healthy elderly persons. Age Ageing. 1996;25:224–230. doi: 10.1093/ageing/25.3.224. - DOI - PubMed
    1. Wei J., Xu H., Davies J.L., Hemmings G.P. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci. 1992;51:1953–1956. doi: 10.1016/0024-3205(92)90112-3. - DOI - PubMed

Publication types