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. 2024 Mar 5;24(1):104.
doi: 10.1186/s12886-024-03367-z.

Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study

Xiao-Bin Zhang  1 , He-He Jiang  1 , Lin-Lin Zhang  1 , Chun-Jing Li  1 , Chen Chen  1 , Meng-Zhen Xing  1 , Yu-Ning Ma #  2 , Yu-Xia Ma #  3
Affiliations

Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study

Xiao-Bin Zhang et al. BMC Ophthalmol. .

Abstract

Background: Myopia is the most prevalent refractive error and a growing global health concern that significantly affects visual function. Researchers have recently emphasized considerably on the influence of lifestyle on myopia incidence and development. This study investigates the relationship between leisure sedentary behaviors (LSB)/physical activity (PA)/sleep traits and myopia.

Methods: LSB, PA, and sleep trait-associated genetic variants were used as instrument variables in a Mendelian randomization (MR) study to examine their causal effects on myopia. Summary genome-wide association studies (GWASs) statistical data for LSB and PA were obtained from UK Biobank, and the data of sleep traits was obtained from UK Biobank, UK Biobank and 23andMe, and FinnGen. We used summary statistics data for myopia from MRC IEU. The MR analyses was performed using the inverse variance-weighted (IVW), MR-Egger, weighted median, and MR Pleiotropy RESidual Sum and Outlier methods.

Results: Computer use was genetically predicted to increase the myopia risk [IVW odds ratio (OR) = 1.057; 95% confidence interval (CI), 1.038-1.078; P = 7.04 × 10- 9]. The self-reported moderate-to-vigorous physical activity (MVPA) (IVW OR = 0.962; 95% CI, 0.932-0.993; P = 1.57 × 10- 2) and television watching (IVW OR = 0.973; 95% CI, 0.961-0.985, P = 1.93 × 10- 5) were significantly associated with a lower myopia risk. However, genetically predicted sleep traits or accelerometer-measured physical activity had no significant associations with myopia.

Conclusion: Our results indicated that computer use is a risk factor for myopia, whereas television watching and MVPA may protect against myopia. These findings shed new light on possible strategies for reducing the prevalence of myopia.

Keywords: Causal relationship; Leisure sedentary behaviors; Mendelian randomization analysis; Myopia; Physical activity; Sleep traits.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Workflow of Mendelian randomization study revealing causality from LSB, PA, and sleep traits on myopia
Fig. 2
Fig. 2
MR analysis of the causal effect of computer use on myopia
Fig. 3
Fig. 3
Odds ratio plot for television watching and myopia
Fig. 4
Fig. 4
Odds ratio plot for MVPA and myopia
See this image and copyright information in PMC

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