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. 2024 Mar 8;24(1):195.
doi: 10.1186/s12888-024-05639-w.

Impacts of inflammatory cytokines on depression: a cohort study

Fei Liu  1 , Yang Yang  2 , Xiao-Wei Fan  3 , Ning Zhang  2 , Shuo Wang  2 , Yi-Jun Shi  4 , Wei-Jiang Hu  2 , Chun-Xue Wang  5
Affiliations

Impacts of inflammatory cytokines on depression: a cohort study

Fei Liu et al. BMC Psychiatry. .

Abstract

Background: Inflammatory factors are associated with depression. We seek to investigate the correlation between inflammatory cytokines and prognosis of depression or suicidal ideation and behavior at 3 months in depression patients.

Methods: Eighty-two depressed outpatients were recruited and treated as usual. Plasma cytokines were measured at baseline. Patients were followed up with Patient Health Questionnaire-9 and suicidal ideation and behavior according to the item 3 of Hamilton depression scale for 3 months.

Results: Compared to the depression patients with low level of interleukin-1β, the high one had severe depressive symptoms at month 2 and 3 (B 0.92, P < 0.01; B 0.86, P = 0.02; respectively). The incidence of suicidal ideation or behavior was 18.3% at 3 months. Depression patients with high levels of tumor necrosis factor-α showed high risk of suicidal ideation and behavior than the low one (OR 2.16, 95% CI 1.00-4.65, P = 0.04).

Conclusions: High levels of interleukin-1β and tumor necrosis factor-α were predictive of middle-term severe depressive symptoms and suicidal ideation and behavior respectively.

Keywords: Depression; Plasma cytokine; Social support; Suicidal ideation and behavior.

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Conflict of interest statement

The authors declare no competing interests.

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