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Review
. 2024 Apr 25;76(2):301-308.

[Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective]

[Article in Chinese]
Yun-Xiao Liu  1 , Jing Lei  1   2 , Hao-Jun You  1   3
Affiliations
  • PMID: 38658378
Free article
Review

[Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective]

[Article in Chinese]
Yun-Xiao Liu et al. Sheng Li Xue Bao. .
Free article

Abstract

Delayed-onset muscle soreness (DOMS) is a common phenomenon that occurs following a sudden increase in exercise intensity or unfamiliar exercise, significantly affecting athletic performance and efficacy in athletes and fitness individuals. DOMS is characterized by allodynia and hyperalgesia, and their mechanisms remain unclear. Recent studies have reported that neurotrophic factors, such as nerve growth factor (NGF) and glial cell derived neurotrophic factor (GDNF), are involved in the development and maintenance of DOMS. This article provides a review of the research progress on the signaling pathways related to the involvement of NGF and GDNF in DOMS, hoping to provide novel insights into the mechanisms underlying allodynia and hyperalgesia in DOMS, as well as potential targeted treatment.

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