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Review
. 2024 Sep 17;17(854):eadp3967.
doi: 10.1126/scisignal.adp3967. Epub 2024 Sep 17.

The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence

Thomas Huber  1 , Mizuho Horioka-Duplix  1   2 , Yuanhuang Chen  1   2 , Victoria R Saca  1   2 , Emilie Ceraudo  1 , Yu Chen  3 , Thomas P Sakmar  1
Affiliations
Review

The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence

Thomas Huber et al. Sci Signal. .

Abstract

In contrast with sun exposure-induced melanoma, rarer melanocytic tumors and neoplasms with low mutational burden present opportunities to study isolated signaling mechanisms. These include uveal melanoma and blue nevi, which are often driven by mutations within the G protein-coupled signaling cascade downstream of cysteinyl leukotriene receptor 2. Here, we review how the same mutations within this pathway drive the growth of melanocytes in one tissue but can inhibit the growth of those in another, exemplifying the role of the tissue environment in the delicate balance between uncontrolled cell growth and senescence.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

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