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Review
. 2024 Sep 24:15:1460631.
doi: 10.3389/fpsyt.2024.1460631. eCollection 2024.

The major biogenic amine metabolites in mood disorders

Jingyi Yang  1 , Minlan Yuan  1 , Wei Zhang  1   2   3
Affiliations
Review

The major biogenic amine metabolites in mood disorders

Jingyi Yang et al. Front Psychiatry. .

Abstract

Mood disorders, including major depressive disorder and bipolar disorder, have a profound impact on more than 300 million people worldwide. It has been demonstrated mood disorders were closely associated with deviations in biogenic amine metabolites, which are involved in numerous critical physiological processes. The peripheral and central alteration of biogenic amine metabolites in patients may be one of the potential pathogeneses of mood disorders. This review provides a concise overview of the latest research on biogenic amine metabolites in mood disorders, such as histamine, kynurenine, and creatine. Further studies need larger sample sizes and multi-center collaboration. Investigating the changes of biogenic amine metabolites in mood disorders can provide biological foundation for diagnosis, offer guidance for more potent treatments, and aid in elucidating the biological mechanisms underlying mood disorders.

Keywords: biogenic amine; bipolar disorder; major depressive disorder; metabolite; mood disorder.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The synthesis and decomposition of kynurenine. TRP, tryptophan; KYN, kynurenine; QUIN, quinolinic acid; KA, kynurenic acid.
Figure 2
Figure 2
The synthesis and biological effects of creatine. Gly, glycine; Arg, arginine; CRT, creatine transporter.
See this image and copyright information in PMC

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