Sodium butyrate inhibits histone deacetylation in cultured cells
- PMID: 667927
- DOI: 10.1016/0092-8674(78)90305-7
Sodium butyrate inhibits histone deacetylation in cultured cells
Abstract
Sodium butyrate in millimolar concentrations causes an accumulation of acetylated histone species in a variety of vertebrate cell lines. In all lines tested, butyrate caused hyperacetylation of H3 and H4, and in rat IRC8 cells, H2A and H2B were also affected. In Friend erythroleukemic cells, butyrate also induces the synthesis of a nonhistone chromosomal protein, IP25. butyrate does not affect the rate of histone acetylation in cell-free extracts of nuclei of Friend cells. Rather, this fatty acid inhibits histone deacetylation. Cell-free extracts of either control cells or butyrate-grown cells contain comparable levels of histone-deacetylating activity. This in vitro activity is inhibited by the addition of butyrate to the extracts. Thus butyrate appears to be an inhibitor of histone deacetylases both in vivo and in vitro.
Similar articles
-
Concentration-dependent effects of sodium butyrate in Chinese hamster cells: cell-cycle progression, inner-histone acetylation, histone H1 dephosphorylation, and induction of an H1-like protein.Biochemistry. 1980 Jun 10;19(12):2656-71. doi: 10.1021/bi00553a019. Biochemistry. 1980. PMID: 7397096
-
Histone proteins determined in a human colon cancer by high-performance liquid chromatography and mass spectrometry.J Chromatogr A. 2006 Sep 29;1129(1):73-81. doi: 10.1016/j.chroma.2006.06.100. Epub 2006 Aug 2. J Chromatogr A. 2006. PMID: 16887128
-
The isolation of HTC variant cells which can replicate in butyrate. Changes in histone acetylation and tyrosine aminotransferase induction.J Biol Chem. 1985 Jun 25;260(12):7698-704. J Biol Chem. 1985. PMID: 2860113
-
Mechanism of the eosinophilic differentiation of HL-60 clone 15 cells induced by n-butyrate.Int Arch Allergy Immunol. 2005;137 Suppl 1:77-82. doi: 10.1159/000085436. Epub 2005 Jun 2. Int Arch Allergy Immunol. 2005. PMID: 15947489 Review.
-
Effects of sodium butyrate, a new pharmacological agent, on cells in culture.Mol Cell Biochem. 1982 Feb 5;42(2):65-82. doi: 10.1007/BF00222695. Mol Cell Biochem. 1982. PMID: 6174854 Review.
Cited by
-
Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A.Blood Adv. 2020 Jun 23;4(12):2644-2655. doi: 10.1182/bloodadvances.2019001144. Blood Adv. 2020. PMID: 32556285 Free PMC article.
-
Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.PLoS One. 2012;7(4):e35240. doi: 10.1371/journal.pone.0035240. Epub 2012 Apr 10. PLoS One. 2012. PMID: 22506074 Free PMC article.
-
Epigenetic manipulation for secondary metabolite activation in endophytic fungi: current progress and future directions.Mycology. 2023 Aug 8;14(4):275-291. doi: 10.1080/21501203.2023.2241486. eCollection 2023. Mycology. 2023. PMID: 38187885 Free PMC article. Review.
-
On the biological role of histone acetylation.Biochem J. 1990 Jan 1;265(1):23-38. doi: 10.1042/bj2650023. Biochem J. 1990. PMID: 2405837 Free PMC article. Review. No abstract available.
-
Dynamically acetylated histones of chicken erythrocytes are selectively methylated.Biochem J. 1991 Feb 1;273 ( Pt 3)(Pt 3):753-8. doi: 10.1042/bj2730753. Biochem J. 1991. PMID: 1996971 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
