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Review
. 1994 Jan;17(1):22-30.
doi: 10.1016/0166-2236(94)90031-0.

Messenger plasticity in primary sensory neurons following axotomy and its functional implications

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Review

Messenger plasticity in primary sensory neurons following axotomy and its functional implications

T Hökfelt et al. Trends Neurosci. 1994 Jan.

Abstract

Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.

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Comment in

  • VIP and messenger plasticity.
    Said SI. Said SI. Trends Neurosci. 1994 Aug;17(8):339. doi: 10.1016/0166-2236(94)90176-7. Trends Neurosci. 1994. PMID: 7526504 No abstract available.

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