Review
doi: 10.1016/0166-2236(94)90031-0.
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
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- PMID: 7511846
- DOI: 10.1016/0166-2236(94)90031-0
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Review
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
Trends Neurosci.
1994 Jan.
Abstract
Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.
Comment in
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VIP and messenger plasticity.Trends Neurosci. 1994 Aug;17(8):339. doi: 10.1016/0166-2236(94)90176-7. Trends Neurosci. 1994. PMID: 7526504 No abstract available.
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