Review
doi: 10.1016/0166-2236(95)93891-z.
Long-term alterations induced by injury and by 5-HT in Aplysia sensory neurons: convergent pathways and common signals?
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- PMID: 7754525
- DOI: 10.1016/0166-2236(95)93891-z
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Review
Long-term alterations induced by injury and by 5-HT in Aplysia sensory neurons: convergent pathways and common signals?
Trends Neurosci.
1995 Mar.
Free article
Abstract
Bodily injury in Aplysia, as in mammals, produces long-lasting memory traces at various neural loci. One consequence of injury, damage to peripheral axons, produces long-term hyperexcitability, synaptic facilitation, and growth in Aplysia sensory neurons. Similar effects are induced in these cells by repeated exposure to 5-HT that is released during aversive learning. An interesting question is to what extent cellular pathways that mediate the effects of axonal injury and 5-HT overlap. One current focus is on identifying cytoplasmic signals that initiate persistent sensory alterations that contribute to both long-term sensitization and memory of injury.
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