Amenorrhea following chemotherapy for breast cancer: effect on disease-free survival
- PMID: 7888312
Amenorrhea following chemotherapy for breast cancer: effect on disease-free survival
Abstract
Adjuvant chemotherapy, which is known to be a cause of premature ovarian failure, is now recommended for most women diagnosed with breast cancer, and it has been postulated that the effects of chemotherapy are of the same order as those of ovarian ablation. Thus, it is important to correlate disease-free survival with induction of early menopause. We examined the literature for papers reporting the effects of chemotherapy on menstruation and ovarian changes in premenopausal women. Few studies reported such effects, but of those papers reviewed here, no such benefits in terms of disease-free survival were found. Thus, the benefits of adjuvant chemotherapy must be carefully weighed against the risk of early menopause in premenopausal women with good prognosis breast cancer.
Similar articles
-
[Observation and clinical significance of adjuvant chemotherapy-induced amenorrhea in premenopausal breast cancer patients].Zhonghua Zhong Liu Za Zhi. 2006 Nov;28(11):848-51. Zhonghua Zhong Liu Za Zhi. 2006. PMID: 17416008 Chinese.
-
Adjuvant endocrine therapy for premenopausal women with early breast cancer.J Clin Oncol. 2005 Mar 10;23(8):1736-50. doi: 10.1200/JCO.2005.11.050. J Clin Oncol. 2005. PMID: 15755982 Review. No abstract available.
-
Ovarian ablation or suppression in premenopausal early breast cancer: results from the international adjuvant breast cancer ovarian ablation or suppression randomized trial.J Natl Cancer Inst. 2007 Apr 4;99(7):516-25. doi: 10.1093/jnci/djk109. J Natl Cancer Inst. 2007. PMID: 17405996 Clinical Trial.
-
Adjunctive chemotherapy as an alternative to ovarian ablation in premenopausal women with carcinoma of the breast.Surg Gynecol Obstet. 1987 Dec;165(6):563-6. Surg Gynecol Obstet. 1987. PMID: 3317947 Review.
-
Undetectable antimüllerian hormone levels and recovery of chemotherapy-induced ovarian failure in women with breast cancer on an oral aromatase inhibitor.Menopause. 2011 Jul;18(7):821-4. doi: 10.1097/gme.0b013e318204af88. Menopause. 2011. PMID: 21326118
Cited by
-
Fertility and the impact of systemic therapy on hormonal status following treatment for breast cancer.Curr Oncol Rep. 2000 Nov;2(6):587-93. doi: 10.1007/s11912-000-0114-9. Curr Oncol Rep. 2000. PMID: 11122897 Review.
-
Relationship of menopausal status and climacteric symptoms to sleep in women undergoing chemotherapy.Support Care Cancer. 2011 Aug;19(8):1107-15. doi: 10.1007/s00520-010-0914-x. Epub 2010 May 29. Support Care Cancer. 2011. PMID: 20508951 Free PMC article.
-
Relationship between reproductive history, anthropometrics, lifestyle factors, and the likelihood of persistent chemotherapy-related amenorrhea in women with premenopausal breast cancer.Fertil Steril. 2012 Jan;97(1):154-9. doi: 10.1016/j.fertnstert.2011.10.005. Fertil Steril. 2012. PMID: 22192139 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical