Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jan;13(1):22-6.
doi: 10.1128/iai.13.1.22-26.1976.

Microbial synergy in experimental intra-abdominal abscess

A B Onderdonk, J G Bartlett, T Louie, N Sullivan-Seigler, S L Gorbach

Microbial synergy in experimental intra-abdominal abscess

A B Onderdonk et al. Infect Immun. 1976 Jan.

Abstract

Intra-abdominal sepsis was studied in Wistar rats by using four microbial species: Escherichia coli, enterococci, Bacteroides fragilis, and Fusobacterium varium. These organisms were implanted into the peritoneal cavity singly and in all possible dual combinations. Results were evaluated by mortality rates and the incidence of intra-abdominal abscesses on autopsy following sacrifice after 7 days. Mortality was restricted to recipients of E. coli, thus implicating coliforms in the acute lethality associated with this experimental model. Intra-abdominal abscesses were produced in 61 of 95 (94%) animals that received the combination of an anaerobe and a facultative organism. Abscesses failed to form with any single strain or with E. coli plus enterococci, and they were detected in one 1 of 19 animals receiving B. fragilis plus F. varium. These results suggest that intra-abdominal abscess formation is related to synergy between anaerobes and facultative bacteria.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Infect Dis. 1958 Jul-Aug;103(1):33-44 - PubMed
    1. Infect Immun. 1974 Dec;10(6):1256-9 - PubMed
    1. Infect Immun. 1974 Dec;10(6):1250-5 - PubMed
    1. Ann Surg. 1938 Apr;107(4):517-28 - PubMed
    1. Br J Exp Pathol. 1967 Dec;48(6):674-9 - PubMed

LinkOut - more resources