Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy
- PMID: 8385540
- DOI: 10.1016/0006-8993(93)91368-3
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy
Abstract
The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intrathecal treatments (beginning 1 h after nerve ligation) with dextrorphan or ketamine (12.5-100 nmol) reliably attenuated hyperalgesia to radiant heat and spontaneous pain-related behaviors in CCI rats. Thermal hyperalgesia also was reduced in CCI rats receiving a single intrathecal treatment with either dextrorphan or ketamine (50 and 100 nmol for each compound) on day 3 after nerve ligation when thermal hyperalgesia was well developed. Since both dextrorphan and ketamine are currently utilized in other clinical applications, the results suggest a new therapeutic utility of these 'old' compounds in treatment of neuropathic pain syndromes resulting from peripheral nerve injury.
Similar articles
-
Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy.Brain Res. 1992 Dec 11;598(1-2):271-8. doi: 10.1016/0006-8993(92)90193-d. Brain Res. 1992. PMID: 1362520
-
Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.Brain Res. 1992 Jul 3;584(1-2):28-53. doi: 10.1016/0006-8993(92)90874-9. Brain Res. 1992. PMID: 1325247
-
Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.Brain Res. 1992 Apr 3;576(2):254-62. doi: 10.1016/0006-8993(92)90688-6. Brain Res. 1992. PMID: 1325239
-
Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat.Neurosci Lett. 1993 Mar 5;151(1):107-10. doi: 10.1016/0304-3940(93)90058-s. Neurosci Lett. 1993. PMID: 8385757
-
[Animal models of neuropathic pain].Nihon Yakurigaku Zasshi. 2006 Mar;127(3):151-5, 146. doi: 10.1254/fpj.127.151. Nihon Yakurigaku Zasshi. 2006. PMID: 16651794 Review. Japanese. No abstract available.
Cited by
-
Antinociceptive interaction of (±)-CPP and propentofylline in monoarthritic rats.Arthritis Res Ther. 2012 Aug 24;14(4):R196. doi: 10.1186/ar4030. Arthritis Res Ther. 2012. PMID: 22920607 Free PMC article.
-
A role of the ubiquitin-proteasome system in neuropathic pain.J Neurosci. 2002 Feb 15;22(4):1363-72. doi: 10.1523/JNEUROSCI.22-04-01363.2002. J Neurosci. 2002. PMID: 11850463 Free PMC article.
-
Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions.Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7731-6. doi: 10.1073/pnas.96.14.7731. Proc Natl Acad Sci U S A. 1999. PMID: 10393889 Free PMC article. Review.
-
Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine.BMC Vet Res. 2013 Mar 27;9:59. doi: 10.1186/1746-6148-9-59. BMC Vet Res. 2013. PMID: 23537119 Free PMC article.
-
Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats.Br J Pharmacol. 1996 Apr;117(7):1487-92. doi: 10.1111/j.1476-5381.1996.tb15311.x. Br J Pharmacol. 1996. PMID: 8730744 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical