How to Manage Atrial Fibrillation Secondary to Ibrutinib

doi:10.1016/j.jaccao.2020.11.016

Review

. 2021 Mar 16;3(1):140-144.

doi: 10.1016/j.jaccao.2020.11.016. eCollection 2021 Mar.

How to Manage Atrial Fibrillation Secondary to Ibrutinib

Hani Essa¹, Taha Lodhi², Rebecca Dobson¹, David Wright¹, Gregory Y H Lip^{1

3}

Affiliations

¹ Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.
² Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.
³ Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

PMID: 34396314
PMCID: PMC8352308
DOI: 10.1016/j.jaccao.2020.11.016

Review

How to Manage Atrial Fibrillation Secondary to Ibrutinib

Hani Essa et al. JACC CardioOncol. 2021.

. 2021 Mar 16;3(1):140-144.

doi: 10.1016/j.jaccao.2020.11.016. eCollection 2021 Mar.

Authors

Hani Essa¹, Taha Lodhi², Rebecca Dobson¹, David Wright¹, Gregory Y H Lip^{1

3}

Affiliations

¹ Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.
² Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.
³ Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

PMID: 34396314
PMCID: PMC8352308
DOI: 10.1016/j.jaccao.2020.11.016

No abstract available

Keywords: AF, atrial fibrillation; BTK, Bruton’s tyrosine kinase; DOAC, direct oral anticoagulant; ECG, electrocardiogram; LMWH, low molecular weight heparin; OR, odds ratio; arrhythmia; echocardiography; treatment.

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Conflict of interest statement

Dr. Wright has received consultancy and speaker fees from Boston Scientific and Medtronic. Prof. Lip has received consultancy and speaker fees from Bayer, Bayer/Janssen, Bristol Myers Squibb/Pfizer, Biotronik, Medtronic, Boehringer Ingelheim, Microlife, Roche, and Daiichi-Sankyo outside the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

**Figure 1**
The ABC Pathway Applied to Oncology Patients The ABC (AF Better Care) pathway can be used to provide holistic management of atrial fibrillation (AF) patients. Step A focuses on avoiding stroke via utilization of the CHA₂DS₂-VASc score and treatment of modifiable bleeding risk factors via the HAS-BLED score. Step B focuses on symptom control in AF and the decision between rate versus rhythm control. Step C focuses on management of modifiable cardiovascular risk factors. Hb = hemoglobin; INR = international normalized ratio.

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References

1. Shah S., Norby F.L., Datta Y.H. Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation. Blood Adv. 2018;2:200–209. - PMC - PubMed
1. Ganatra S., Sharma A., Shah S. Ibrutinib-associated atrial fibrillation. J Am Coll Cardiol EP. 2018;4:1491–1500. - PubMed
1. Zamorano J.L., Lancellotti P., Rodriguez Muñoz D. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: the Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC) Eur Heart J. 2016;37:2768–2801. - PubMed
1. Perez M.V., Mahaffey K.W., Hedlin H. Large-scale assessment of a smartwatch to identify atrial fibrillation. N Engl J Med. 2019;381:1909–1917. - PMC - PubMed
1. Malavasi V.L., Fantecchi E., Gianolio L. Atrial fibrillation in patients with active malignancy and use of anticoagulants: under-prescription but no adverse impact on all-cause mortality. Eur J Intern Med. 2019;59:27–33. - PubMed

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[1] Shah S., Norby F.L., Datta Y.H. Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation. Blood Adv. 2018;2:200–209. - PMC - PubMed

[2] Shah S., Norby F.L., Datta Y.H. Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation. Blood Adv. 2018;2:200–209. - PMC - PubMed

[3] Ganatra S., Sharma A., Shah S. Ibrutinib-associated atrial fibrillation. J Am Coll Cardiol EP. 2018;4:1491–1500. - PubMed

[4] Ganatra S., Sharma A., Shah S. Ibrutinib-associated atrial fibrillation. J Am Coll Cardiol EP. 2018;4:1491–1500. - PubMed

[5] Zamorano J.L., Lancellotti P., Rodriguez Muñoz D. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: the Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC) Eur Heart J. 2016;37:2768–2801. - PubMed

[6] Zamorano J.L., Lancellotti P., Rodriguez Muñoz D. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: the Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC) Eur Heart J. 2016;37:2768–2801. - PubMed

[7] Perez M.V., Mahaffey K.W., Hedlin H. Large-scale assessment of a smartwatch to identify atrial fibrillation. N Engl J Med. 2019;381:1909–1917. - PMC - PubMed

[8] Perez M.V., Mahaffey K.W., Hedlin H. Large-scale assessment of a smartwatch to identify atrial fibrillation. N Engl J Med. 2019;381:1909–1917. - PMC - PubMed

[9] Malavasi V.L., Fantecchi E., Gianolio L. Atrial fibrillation in patients with active malignancy and use of anticoagulants: under-prescription but no adverse impact on all-cause mortality. Eur J Intern Med. 2019;59:27–33. - PubMed

[10] Malavasi V.L., Fantecchi E., Gianolio L. Atrial fibrillation in patients with active malignancy and use of anticoagulants: under-prescription but no adverse impact on all-cause mortality. Eur J Intern Med. 2019;59:27–33. - PubMed

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How to Manage Atrial Fibrillation Secondary to Ibrutinib

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How to Manage Atrial Fibrillation Secondary to Ibrutinib

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