The use of pindolol to potentiate antidepressant medication
- PMID: 9635544
The use of pindolol to potentiate antidepressant medication
Abstract
Serotonin (5-HT) selective reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors are thought to have a delayed onset of antidepressant action attributable in part to the decrease in firing activity of 5-HT neurons they produce upon treatment initiation. As cell body 5-HT1A autoreceptors desensitize, 5-HT neuronal firing is restored. The agent pindolol, through its 5-HT1A receptor blocking property, has been shown to prevent the initial decrease in firing of rat 5-HT neurons associated with SSRI treatment. Four open-label studies put into evidence a significant acceleration of the antidepressant effect of SSRIs when combined with pindolol. Four of five placebo-controlled studies have confirmed this observation. Controlled trials indicate that a greater rate of response may be obtained by combining pindolol from the beginning of the SSRI treatment. The strategy of adding pindolol to the regimen of SSRI-resistant patients also appears to produce a therapeutic effect in a significant proportion of patients.
Similar articles
-
Pindolol, 5-hydroxytryptamine, and antidepressant augmentation.Arch Gen Psychiatry. 1995 Nov;52(11):969-71. doi: 10.1001/archpsyc.1995.03950230083012. Arch Gen Psychiatry. 1995. PMID: 7487345 No abstract available.
-
[Interest of the use of pindolol in the treatment of depression: review].Encephale. 2003 Jul-Aug;29(4 Pt 1):338-50. Encephale. 2003. PMID: 14615704 Review. French.
-
Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response.Neuropsychopharmacology. 1997 May;16(5):333-8. doi: 10.1016/S0893-133X(96)00242-4. Neuropsychopharmacology. 1997. PMID: 9109104
-
Pharmacology of rapid-onset antidepressant treatment strategies.J Clin Psychiatry. 2001;62 Suppl 15:12-7. J Clin Psychiatry. 2001. PMID: 11444761 Review.
-
Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats.Neurochem Int. 2009 Mar-Apr;54(3-4):161-71. doi: 10.1016/j.neuint.2008.08.012. Epub 2008 Nov 27. Neurochem Int. 2009. PMID: 19073228 Free PMC article.
Cited by
-
Effects of sustained (+/-)pindolol administration on serotonin neurotransmission in rats.J Psychiatry Neurosci. 2000 Sep;25(4):378-88. J Psychiatry Neurosci. 2000. PMID: 11022403 Free PMC article.
-
Therapeutic options for treatment-resistant depression.CNS Drugs. 2010 Feb;24(2):131-61. doi: 10.2165/11530280-000000000-00000. CNS Drugs. 2010. PMID: 20088620 Review.
-
Genetic approaches for understanding the role of serotonin receptors in mood and behavior.Curr Opin Neurobiol. 2013 Jun;23(3):399-406. doi: 10.1016/j.conb.2013.01.011. Epub 2013 Feb 4. Curr Opin Neurobiol. 2013. PMID: 23385115 Free PMC article. Review.
-
Strategy to Accelerate or Augment the Antidepressant Response and for An Early Onset of SSRI Activity. Adjunctive Amisulpride to Fluvoxamine in Major Depressive Disorder.Clin Pract Epidemiol Ment Health. 2010 Jan 27;6:1-3. doi: 10.2174/1745017901006010001. Clin Pract Epidemiol Ment Health. 2010. PMID: 20498696 Free PMC article.
-
The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency?Mol Neurobiol. 2000 Jun;21(3):137-52. doi: 10.1385/mn:21:3:137. Mol Neurobiol. 2000. PMID: 11379796 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
