Neuronal nicotinic receptors: from protein structure to function
Abstract
Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structure–function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structure–function relationship of these receptors and their implication in neurological diseases.
- Publication:
-
FEBS Letters
- Pub Date:
- January 2001
- DOI:
- Bibcode:
- 2001FEBSL.504..118I
- Keywords:
-
- Neuronal nicotinic acetylcholine receptor;
- Ligand-gated channel;
- Transmission;
- Molecular structure;
- ACh;
- acetylcholine;
- nAChR;
- nicotinic acetylcholine receptor;
- GABA;
- γ-aminobutyric acid;
- GluRCl;
- chloride permeable glutamate receptor;
- glyR;
- glycine receptor;
- α-Bgt;
- α-bungarotoxin;
- 5HT 3;
- 5-hydroxytryptamine