IEEE/ACM Transactions on Computational Biology and Bioinformatics

IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB) is a bimonthly journal that publishes archival research results related to the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology. Read the full scope of TCBB

TCBB seeks editor in chief for 2017-2018 term

The IEEE Computer Society, IEEE Engineering in Medicine and Biology Society, and Association for Computing Machinery seek applicants for the position of editor in chief of the IEEE Transactions on Computational Biology and Bioinformatics, serving a two-year term starting 1 January 2017, renewable once. Please view the EIC Search Ad for more information or contact Kimberly Sperka, [email protected]. Extended Deadline: 1 April 2016

IEEE Transactions on Computational Biology and Bioinformatics (TCBB) moved to the OnlinePlus publication model starting with 2015 issues!

From the January/February 2016 Issue

Predicting Hub Genes Associated with Cervical Cancer through Gene Co-Expression Networks

By Su-Ping Deng, Lin Zhu, and De-Shuang Huang

Cervical cancer is the third most common malignancy in women worldwide. It remains a leading cause of cancer-related death for women in developing countries. In order to contribute to the treatment of the cervical cancer, in our work, we try to find a few key genes resulting in the cervical cancer. Employing functions of several bioinformatics tools, we selected 143 differentially expressed genes (DEGs) associated with the cervical cancer. The results of bioinformatics analysis show that these DEGs play important roles in the development of cervical cancer. Through comparing two differential co-expression networks (DCNs) at two different states, we found a common sub-network and two differential sub-networks as well as some hub genes in three sub-networks. Moreover, some of the hub genes have been reported to be related to the cervical cancer. Those hub genes were analyzed from Gene Ontology function enrichment, pathway enrichment and protein binding three aspects. The results can help us understand the development of the cervical cancer and guide further experiments about the cervical cancer.

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Editorials and Announcements

Announcements

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Editorials

• Editorial from the Editor-in-Chief by Y. Xu (January/February 2015)
• Reviewer Appreciation Editorial by Y. Xu (July/August 2014)
• EIC Editorial by M.-F. Sagot (March/April 2011)
• EIC Editorial by M.-F. Sagot (January/February 2011)

Guest Editorials

• Special Section on the 10th International Conference on Intelligent Computing (ICIC) (Jan/Feb 2016)
• 13th Asia Pacific Bioinformatics Conference (Nov/Dec 2015)
• Knowledge Discovery Using Big Data in Biomedical Systems (July/August 2015)
• TCBB Special Section on the Brazilian Symposium on Bioinformatics 2013 (May/June 2015)
• Special Section on BIBM 2013 (March/April 2015)
• Selected Papers from ACM-BCB 2013 (Jan/Feb 2015)
• Special Section on BIOKDD2013 (Sept/Oct 2014)
• 12th Asia Pacific Bioinformatics Conference (July/August 2014)
• Pattern Recognition in Bioinformatics (May/June 2014)
• Special Section on Bioinformatics Research and Applications (May/June 2014)
• Bioinformatics and Computational Systems Biology (July/August 2012)
• High Performance Computational Systems Biology (May/June 2012)
• Special Section on Bioinformatics Research and Applications (July/August 2011)
• Special Focus on Bioinformatics and Systems Biology (March/April 2011)
• Special Section on Bioinformatics Research and Applications (Oct/Dec 2010)

Reviewers List

• 2015 TCBB Reviewers List (PDF)

Author Index

• 2015 TCBB Annual Index (PDF)

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TCBB is a joint publication of the IEEE Computer Society, Association for Computing Machinery, IEEE Computational Intelligence Society, and the IEEE Engineering in Medicine and Biology Society.

Published in cooperation with: IEEE Control Systems Society

Indexed in MEDLINE®/PubMed® & ISI