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. 2002 Mar 2;324(7336):545. doi: 10.1136/bmj.324.7336.545/a

Quality of Cochrane reviews

Quality of Cochrane reviews is better than that of non-Cochrane reviews

Mark Petticrew 1,2,3, Paul Wilson 1,2,3, Kath Wright 1,2,3, Fujian Song 1,2,3
PMCID: PMC1122457  PMID: 11872564

Editor—Olsen et al assessed a sample of Cochrane reviews from 1998 and highlighted some areas where improvement is possible.1 They found that 29% of reviews had major problems, including inappropriate methods and conclusions. As they say, improvement is still possible, but this figure nevertheless represents a major improvement on the quality of non-Cochrane reviews.

We have reviewed the methods of 480 systematic reviews on the database of abstracts of reviews of effectiveness (DARE) at the University of York.2,3 Methodological details of the reviews were coded and checked by two reviewers working independently. We found that only half (52%) of the reviews had systematically assessed the validity of the included studies; that most systematic reviews were unlikely to be comprehensive (they had searched either one or two databases); and that overall only a quarter (26%) of reviews met three key methodological criteria (relating to a thorough search, assessment of the validity of the included studies, and investigation of heterogeneity). Narrative reviews were less likely to meet all three criteria (20% v 30%, P=0.02) and more likely to be coded by raters as inconclusive.

Up to half of non-Cochrane reviews are thus potentially misleading. Against this, Olsen et al's estimate of 29% for Cochrane reviews compares favourably. Although more recent research syntheses are likely to be of higher quality, particularly if reviewers follow current guidelines,4,5 problems with the reliability of systematic reviews will probably remain. Since our study was conducted the criteria for including systematic reviews on the database of abstracts of reviews of effectiveness have been revised (from October 2000 onwards) to ensure that only reviews of potentially high methodological quality are included.

We would support Olsen et al's suggestion that users of any systematic review should assess its reliability. We would also recommend that for a critical assessment of the quality of non-Cochrane reviews users should first look at the database of abstracts of reviews of effectiveness.

References

  • 1.Olsen O, Middleton P, Ezzo J, Gøtzsche PC, Hadhazy V, Herxheimer A, et al. Quality of Cochrane reviews: assessment of sample from 1998. BMJ. 2001;323:829–832. doi: 10.1136/bmj.323.7317.829. . (13 October.) [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.DARE database. http://nhscrd.york.ac.uk/welcome.htm.
  • 3.Petticrew M, Song F, Wilson P, Wright K. The DARE database of abstracts of systematic reviews: a summary and analysis. Int J Technol Assess Health Care. 2000;15:671–678. [PubMed] [Google Scholar]
  • 4.Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF.for the QUOROM Group. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement Lancet 19993541896–1900. [DOI] [PubMed] [Google Scholar]
  • 5.NHS Centre for Reviews and Dissemination. Undertaking systematic reviews of research on effectiveness: CRD's guidance for those carrying out or commissioning reviews. York: CRD; 2001. . (Report No 4 (2nd ed).) [Google Scholar]
BMJ. 2002 Mar 2;324(7336):545.

Another study found that most Cochrane reviews are of a good standard

Helen Handoll 1,2, Rajan Madhok 1,2

Editor—We would extend Olsen et al's observations on Cochrane reviews.1-1 Last year we undertook a study of the utility of the Cochrane Database of Systematic Reviews in informing health policy and practice.1-2 We produced summary documents listing the conditions or diseases reviewed; the statements of evidence and effect; and, where available, conclusions for policy and practice for the reviews from collaborative review groups that covered cancer (including tobacco addiction), vascular disease, and fractures. In assessing the Cochrane reviews we scrutinised high profile sections (review title, abstract, objectives, conclusions, synopsis), just as a busy healthcare professional would do.

When necessary we inspected other sections of the review. Although we did not critically appraise review methodology, we recorded any errors, discrepancies (including discordance between the conclusions of effect and the available evidence), and other items needing clarification. We reported such information direct to the coordinators of the collaborative review groups.

We sent specific comments on 62 of the 159 reviews processed in Issue 2, 2000, of the Cochrane Library. Although most comments were minor, the inappropriate interpretation of results leading to spurious conclusions was considered likely in two reviews, the disregard of problems with the unit of analysis was thought likely in four, and sections were missing in two. Failure to collect outcome data on adverse effects of treatment and quality of life and function was also commented on in several reviews.

Our experience confirms that most Cochrane reviews are of a good standard. This is a considerable achievement, especially given the unpaid and voluntary nature of the work. The regularly updated electronic publication and the comments and criticisms facility offer great advantages. For instance, in cases where reviews with serious defects cannot be remedied speedily their temporary removal is important. Like Olsen et al, we emphasise the importance of feedback from users of the Cochrane Library.

Finally, Olsen et al conclude that readers should themselves assess the reliability of individual Cochrane reviews, and they emphasise the need to learn the skills of critical appraisal. We support their recommendation, but we are concerned that this may seem like advice to let the buyer beware. Given the broad readership (including lay people) of Cochrane reviews, the main emphasis must be on good quality and reliable reviews that people can trust.

Footnotes

Both authors are affiliated to the Cochrane Musculoskeletal Injuries Group: HH was the previous coordinator of the collaborative review group, RM is an editor, and both are active reviewers. The views expressed in the letter are the authors'.

References

  • 1-1.Olsen O, Middleton P, Ezzo J, Gøtzsche PC, Hadhazy V, Herxheimer A, et al. Quality of Cochrane reviews: assessment of sample from 1998. BMJ. 2001;323:829–832. doi: 10.1136/bmj.323.7317.829. . (13 October.) [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 1-2.Handoll H, Madhok R. Utility of the Cochrane Database of Systematic Reviews for evidence-based health policy and practice: a case study. J Clin Excel. 2001;3:59–68. [Google Scholar]

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